Inhibition of Na+/K+ ATP ase pump by the cardiac glycosides
results in the increased concentration of intracellular sodium, leading to the influx of calcium in the intracellular compartment and its release to the sarcoplasm.
A brown ring obtained in the interface indicated the presence of cardiac glycosides
stem Phytochemical component Methanolic extract Alkaloids Present Tannins Absent Phenolics Present Cardiac glycosides
Present Phlobatanins Absent Flavonoids Present Terpenoid Present Steroid Present Reducing sugar Absent Table 2.
Results: In this study, we found that Cardiac glycosides
, particularly Lanatoside C from Digitalis ferruginea could significantly inhibit PTEN protein adequate Huh7 and PTEN deficient Mahlavu human liver cancer cell proliferation by the induction of apoptosis and G2/M arrest in the cells.
(2) Conventional therapy for congestive heart failure includes diuretics and angiotensin converting enzyme inhibitors, which are combined on occasion with a cardiac glycoside
. Digoxin is the most commonly prescribed cardiac glycoside
Different plant Tests constituents Test for alkaloids Mayer's test, Dragendroff's test, Wagner's test, and Hager's test Test for proteins and Millon's test, Biuret test, and amino acids ninhydrin test Test for anthraquinones Modified Borntrager's test Test for flavonoids Ferric chloride test and lead acetate test Test for carbohydrates Molisch's test Test for reducing sugars Fehling's test and Benedict's test Test for saponins Foam formation test Test for tannins Ferric chloride test and lead acetate test Test for steroids, Liebermann-Burchard test, triterpenoids, and Salkowski test, Noller's test, cardiac glycosides
Legal's test, Baljet test, and Keller Kiliani's test TABLE 2: Effect on electrolyte excretion in urine.
Schoner, "Endogenous cardiac glycosides
, a new class of steroid hormones," European Journal of Biochemistry, vol.
, also known as digitalis glycosides, have been used to treat heart conditions in the medical world for at least 2,000 years.
Standard phytochemical methods were used to test for the presence of saponins, alkaloids, tannins, anthraquinones, cardiac glycosides
, cyanogenetic glycosides and flavonoids, following standard methods, as described below:
The confirmatory tests were on alkaloids, saponins, tannins, anthraquinones, cardiac glycosides
, flavonoids, and terpenes.
Patients with known ischemic heart disease, systemic hypertension,valvular heart disease,hyperkalemia ,conduction defects and those on drugs like beta blockers, cardiac glycosides
, calcium channel blockers and anti arrhythmic drugs were excluded from the study.
Antidotes are only of potential value in the treatment of plants containing cardiac glycosides
and those that present with cholinergic and anticholinergic toxidromes.