cardiac glycoside


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Related to cardiac glycoside: digitalis, digoxin

glycoside

 [gli´ko-sīd]
any compound containing a carbohydrate molecule (sugar), particularly any such natural product in plants, convertible, by hydrolytic cleavage, into a sugar and a nonsugar component (aglycone), and named specifically for the sugar contained, such as fructoside (fructose), glucoside (glucose), or pentoside (pentose).
cardiac glycoside any of a group of glycosides occurring in certain plants (Digitalis, etc.), having a characteristic action on the contractile force of the heart muscle.

cardiac glycoside

n.
Any of several glycosides obtained chiefly from plant sources such as the foxglove, used medicinally to increase the force of contraction of heart muscle and to regulate heartbeats.

cardiac glycoside

Pharmacology A drug that blocks the Na+/K+ pump

cardiac glycoside

positive inotrope drug which increases force of cardiac contraction and reduces atrioventricular node conductivity; used to control atrial fibrillation, e.g. digoxin

glycoside

any compound containing a carbohydrate moiety (sugar), particularly any such natural product in plants, convertible, by hydrolytic cleavage, into a sugar and a nonsugar component (aglycone), and named specifically after the sugar contained, as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc.

cardiac glycoside
any one of a group of glycosides occurring in certain plants (e.g. Digitalis) having a characteristic action on the contractile force of the heart muscle. See also cardenolide, bufadienolide.
References in periodicals archive ?
In this study, drug resistant PTEN deficient mesenchymal like Mahlavu liver cancer cells and drug sensitive PTEN adequate Huh7 cells were selected to be studied in depth including the molecular pathways involved in cell death in the presence of cardiac glycoside Lanatoside C (Buontempo et al.
Cardiac glycosides also can be prescribed as anti-arrhythmics for certain common atrial dysrhythmias, such as atrial flutter and atrial fibrillation; its parasympathomimetic actions increase the vagal tone to the sinoatrial and AV node.
With the exception of animal-derived, digoxin-specific Fab antibodies to inactivate ingested plant-derived cardiac glycosides and physostigmine to reverse plant toxin-induced central anticholinergic syndromes, there are few remaining effective antidotes for most plant toxins.
Plant-derived cardiac glycosides such as digoxin are used for the treatment of congestive heart failure and other cardiac disorders (1).
5,6,7,8,9,10,11,12,13) Page stated that cardiac glycosides specifically inhibit the active transport of Na+ out of the heart muscle cells resulting in a net cellular accumulation of Na and secondarily a net cellular loss of K.
This study has reported the detoxification of Thevetia seed meal as well as a quantification of the cardiac glycoside content in the treated and untreated samples.
2) describe studies that support the possibility of de novo biosynthesis, in the adrenal, of a material whose overall physicochemical, immunocrossreactive, and chromatographic characteristics are indistinguishable from those of the cardiac glycoside (CG) digoxin and its dihydro analog (in which the lactone ring is fully saturated).
The risk of cardiac glycoside cumulation must be given serious attention especially with elderly patients; indications should be definite before writing prescriptions.
While the chemical identity of the inhibitor remained a mystery, the team's data suggested the compound had physiological effects similar to those of a cardiac glycoside called digitalis.
The third application is for "Compositions and Methods Using a Cardiac Glycoside.