cardiac glycoside


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Related to cardiac glycoside: digitalis, digoxin

glycoside

 [gli´ko-sīd]
any compound containing a carbohydrate molecule (sugar), particularly any such natural product in plants, convertible, by hydrolytic cleavage, into a sugar and a nonsugar component (aglycone), and named specifically for the sugar contained, such as fructoside (fructose), glucoside (glucose), or pentoside (pentose).
cardiac glycoside any of a group of glycosides occurring in certain plants (Digitalis, etc.), having a characteristic action on the contractile force of the heart muscle.

cardiac glycoside

n.
Any of several glycosides obtained chiefly from plant sources such as the foxglove, used medicinally to increase the force of contraction of heart muscle and to regulate heartbeats.

cardiac glycoside

Pharmacology A drug that blocks the Na+/K+ pump
References in periodicals archive ?
Cardiovascular signs originate due to the activity of the cardiac glycosides. Their mechanism of action is based on the inhibition of sodium-potassium pump (Na/K-ATPase), resulting in depletion of intracellular potassium and increased level of intracellular sodium.
Cardiac glycosides help improve symptoms of congestive heart failure, but do not necessarily lower the rate of patient mortality (Adams & Holland, 2011).
With the exception of animal-derived, digoxin-specific Fab antibodies to inactivate ingested plant-derived cardiac glycosides and physostigmine to reverse plant toxin-induced central anticholinergic syndromes, there are few remaining effective antidotes for most plant toxins.
Interestingly, these events occur at nontoxic (nanomolar) concentrations, well below the concentrations of any reported toxic complications encountered with therapeutic cardiac glycoside doses.
(5,6,7,8,9,10,11,12,13) Page stated that cardiac glycosides specifically inhibit the active transport of Na+ out of the heart muscle cells resulting in a net cellular accumulation of Na and secondarily a net cellular loss of K.
This study has reported the detoxification of Thevetia seed meal as well as a quantification of the cardiac glycoside content in the treated and untreated samples.
While the chemical identity of the inhibitor remained a mystery, the team's data suggested the compound had physiological effects similar to those of a cardiac glycoside called digitalis.
The results revealed that methanolic extract and fractions of plant were rich in alkaloids, tannins, quinones, flavonoids, saponins, coumarins cardiac glycoside and terpenoids.
The fruit resembles mango--the kernel contains various toxic principles, the important one is Cerberin, a cardiac glycoside almost similar in toxicity to digitalis found in Foxglove.
Cardiac glycoside are the most important toxic compounds of the oleander.
We also compared the effect of [TA.sub.AqE] with well-known cardiotonics, isoproterenol (ISO), a [beta]-adrenergic agonist, and ouabain (Ouab), a cardiac glycoside for the underlying mechanism, efficacy and safety.
Both EIAs were based on the competitive binding of free cardiac glycosides (ouabain/dihydroouabain) or free mammalian cardenolides (OLF/Dh-OLF) in the sample and bound cardiac glycoside to a constant amount of the respective antibodies in the EIAs.