Importantly, the INOS2 CLS derives
cardiac contractility information by using an elegant and simple beat-by-beat measurement of ventricular intracardiac impedance.
Cardiac contractility is driven by the cardiac sarcomere, a highly ordered cytoskeletal structure composed of cardiac myosin, actin and a set of regulatory proteins, and is the fundamental unit of muscle contraction in the heart.
Using their advanced understanding of
cardiac contractility, we hope to develop therapies that will improve the lives of heart failure patients around the world.
Like TRV027 in rats, TRV120023 also increased
cardiac contractility in mice in a -arrestin-dependent manner.
Overtreatment with levothyroxine sodium may have adverse cardiovascular effects such as an increase in heart rate, cardiac wall thickness, and
cardiac contractility and may precipitate angina or arrhythmias.
3] alone depressed
cardiac contractility (dP/dt) in the isolated perfused heart.
Moreover, SRG significantly reduced the level of cardiac Troponin I (cTnl) in the serum, which suggests that cTnl, a protein component of the troponin regulatory complex involved in
cardiac contractility, contributes to the SRGmediated recovery of cardiac systolic function.
Most inotropic drugs increase
cardiac contractility by increasing the level of intracellular cyclic adenosine monophosphate (cAMP) (32).
The main regulator of SERCA2a is phospholamban, which has been accepted as a key regulator of SERCA2a and
cardiac contractility.
Spindler and his research team used Affymetrix microarrays as well as biochemical and histological studies to show that CR rapidly changes cardiac gene expression and physiology to reduce cardiovascular damage, fibrosis, and blood pressure, and to enhance
cardiac contractility and energy production.
1-2) Hyperthyroidism commonly causes a sustained hyperkinetic circulatory state resulting both from the direct effect of thyroid hormone on
cardiac contractility and rate, as well as an indirect effect on peripheral circulation leading to increased blood volume and vasodilation.
Recently devices that provide sub-pacing impulses to the failing myocardium in animals have improved
cardiac contractility in humans and are under clinical testing.
