Impulse Dynamics added that the Optimizer has been successfully implanted in over 3,500 patients worldwide to date and the
Cardiac Contractility Modulation therapy is approved for sale in Europe, Australia, Brazil, India, New Zealand and Hong Kong.
Marban, "Chronic treatment with allopurinol boosts survival and
cardiac contractility in murine postischemic cardiomyopathy," Circulation Research, vol.
A recombinant antibody increases
cardiac contractility by mimicking phospholamban phosphorylation.
In addition, other studies have reported that experimental hypertension is associated with normal (25) or increased (8)
cardiac contractility.
Poor
cardiac contractility may result in inability to cope with large fluid volumes.
Cardiac contractility is compromised in cirrhotic patients and manifests clinically under stressful situations.
D-ribose improves
cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats.
Cardiac contractility, measured as the rate of pressure generation in the heart, dP/dt, also increases substantially.
Vasodilation decreases total peripheral resistance, while a decrease in
cardiac contractility decreases cardiac output.
This study showed that administration of COC improved
cardiac contractility and left ventricular function, evidenced by the increase in CF and LVDP, possibly via scavenging free radicals and thereby reducing reperfusion-induced injury to the myocardium.
The goals are to maintain
cardiac contractility and avoid sudden changes in afterload and preload.
Anxiety can increase the patient's heart rate and
cardiac contractility, leading to increased blood pressure and temperature, flushing, and sweating (Vaughn et al.
