carcinosarcoma


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carcinosarcoma

 [kahr″sĭ-no-sahr-ko´mah]
a malignant tumor composed of carcinomatous and sarcomatous tissues.
embryonal carcinosarcoma Wilms' tumor.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

car·ci·no·sar·co·ma

(kar'si-nō-sar-kō'mă),
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue.
See also: collision tumor.
Farlex Partner Medical Dictionary © Farlex 2012

carcinosarcoma

A biphasic tumor consisting of malignant epithelial and mesenchymal elements which may occur in the lungs, uterus, and elsewhere.
 
ENT Salivary gland
True malignant mixed tumour A rare, highly aggressive tumour of the older to elder which may be associated with pleomorphic adenoma; the carcinoma component is usually glandular; the sarcoma component is usually chondrosarcomatous. Mortality ±50%
Gastroenterology A type of carcinoma of the oesophagus which, like conventional squamous cell carcinomas, is more common in middle-aged to older men.
Lung A malignant tumour having a mixture of carcinoma and sarcoma, the latter containing heterologous elements such as malignant cartilage, bone or skeletal muscle (WHO 1999).
Urology A rare malignant tumour that is more common in older males—70 cases reported in the world literature. It presents in advanced stage, is a rapidly growing polypoid tumour and has a poor prognosis. The epithelial component is usually a high-grade transitional cell carcinoma with epidermoid and/or glandular differentiation. The heterologous component consists of chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, leiomyosarcoma, fibrosarcoma, or rhabdomyosarcoma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

car·ci·no·sar·co·ma

(kahr'si-nō-sahr-kō'mă)
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Patterns of failure for conservatively managed surgical stage I uterine carcinosarcoma: implications for adjuvant therapy.
In conclusion, we report a case of gallbladder carcinosarcoma with an osteoid component, which was treated by surgical resection.
According to the post-operative pathology report, patients whose tumor histology was defined as serous or carcinosarcoma were selected for the study.
However, endometrioid carcinomas accounted for 47% of uterine cancers among black women, who had a higher percentage of other carcinomas, carcinosarcomas, and sarcomas than did women in other racial/ethnic groups.
A physician in another hospital performed uterine artery embolization and biopsied the mass, which was shown to be a uterine carcinosarcoma. The vaginal hemorrhage decreased significantly postoperatively.
Out of the 56 cases studied, 49 (87.5%) were Endometroid Carcinoma, 3 ((5.36%) were Serous Carcinoma, 2 (3.57%) cases were of Carcinosarcoma, 1 (1.79%) case each of Clear cell Carcinoma and Mucinous Carcinoma.
Carcinosarcoma is a rare neoplasm composed of carcinomatous and sarcomatous cellular components.
Hashimura et al., "Cooperation of Sox4 with (3-catenin/p300 complex in transcriptional regulation of the Slug gene during divergent sarcomatous differentiation in uterine carcinosarcoma," BMC Cancer, vol.
The treatment of uterine carcinosarcoma, namely malignant mixed mullerian tumor with metastatic solitary bone metastasis to the calcaneus, consisted of wide surgical excision followed by adjuvant chemotherapy and radiotherapy [7].
A malignant biphasic neoplasm consisting of an epithelial (squamous) element and mesenchymal component is known as a carcinosarcoma (also known as pleomorphic carcinoma, spindle cell carcinoma, pseudosarcoma, and pseudosarcomatous squamous cell carcinoma) [1, 2] although the exact nomenclature and subclassifications are variable [3].
Carcinosarcoma in the other variants is an extremely rare neoplasm of the urinary bladder, accounting for 0.1 to 0.3% of all bladder malignancies [2, 3].
Type 2 ovarian cancer includes poorly differentiated serous adenocarcinoma, poorly differentiated endometrioid adenocarcinoma, undifferentiated carcinoma, and carcinosarcoma. It is considered that most serous adenocarcinomas are derived from the fallopian tube epithelium and that many serous adenocarcinomas are accompanied by a p53 mutation and tend to show peritoneal seeding from the initial stage.