Carbonyl chemistry,
carboxylic acid derivatives, and carbohydrates are discussed before concluding with special topics in biochemistry, orbital symmetry, and intramolecular reactions.
In acidic solution, the weak nucleophile water attacks carbonyl carbon atom, having protonated oxygen atom; then
carboxylic acid derivatives and alcohol groups are formed [28].
Similarly, the Sr-mediated esterification was used successfully with bulky tert-alcohols with
carboxylic acid derivatives. Esterification of secondary and tertiary alcohols is notoriously difficult but they are fundamental organic synthesis reactions.