Carboxylesterase 2 | definition of carboxylesterase 2 by Medical dictionary
CES1 (redirected from carboxylesterase 2)
CES1 A gene on chromosome 16q22.2 that encodes a member of the carboxylesterase family, which hydrolyse or transesterify xenobiotics (e.g., cocaine and heroin) and endogenous substrates with ester,
thioester or amide bonds. CES1 may participate in fatty acyl and cholesterol ester metabolism, and may play a role in maintaining the blood-brain barrier. It is the major liver enzyme and functions in liver drug clearance.
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References in periodicals archive
McLeod, "Human carboxylesterase 2
is commonly expressed in tumor tissue and is correlated with activation of irinotecan," Clinical Cancer Research, vol.
Li et al., "Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2
," Fitoterapia, vol.
Kang S, Kim YH, Lee HJ, Kim BJ, Lim KJ, Lee SH (2012) Onestep identification of B and Q biotypes of Bemisia tabaci based on intron variation of carboxylesterase 2