Lactic acidosis and PAA along with the MRI findings prompted the differential diagnosis of pyruvate carboxylase
deficiency (PCD), which was confirmed by PC gene sequencing.
Induced polymerization of mammalian acetyl-CoA carboxylase
by MIG12 provides a tertiary level of regulation of fatty acid synthesis.
Two important enzymes in the fat synthesis pathway are acetyl-CoA carboxylase
Adipocyte RNA was analyzed for relative expression of DIO2, a gene associated with endocrine function (LEPTIN, ADIPOQ), mitochondrial function (cell death activator (CIDEA), ATP synthase (ATP5A), and carnitine palmitoyltransferase 1B (CPT1B)), fatty acid [beta]-oxidation (acetyl CoA dehydrogenase (ACADM)), fatty acid synthesis (acetyl-CoA carboxylase
(ACC2), fatty acid synthase (FASN), and diglyceride acyltransferase (DGAT)), adipocyte function (PPARgamma (PPAR[gamma])), innate immunity (NLRP3), and select proinflammatory or anti-inflammatory cytokines or chemoattractants (tumor necrosis factor alpha (TNF[alpha]), interleukin-1[beta] (IL-1[beta]), and plasminogen activator inhibitor-1 (PAI-1)).
This will induce energy-generating pathways by rapid phosphorylation of acetyl coA carboxylases
1 and 2 (ACC1 and ACC2) and phosphofructokinase (PFK), which lead to decreased fatty acid synthesis, increased fatty acid oxidation, and increased glycolysis.
Also in the liver, fructose induces mRNA expression from Glut-2, Glut-5, fatty acid synthase (FAS), and acetyl-CoA carboxylase
Sasaki, "Compartmentalization of two forms of acetyl-CoA carboxylase
in plants and the origin of their tolerance toward herbicides," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
They are known as aryloxyphenoxypropionate herbicides, and acetyl-CoA carboxylase
DRM01 is a novel topical inhibitor of acetyl coenzyme-A carboxylase
, an enzyme involved in synthesis of the fatty acids that are an essential component of sebum.
Suormala, "Multiple carboxylase
deficiency: inherited and acquired disorders of biotin metabolism," International Journal for Vitamin and Nutrition Research, vol.
Acetyl CoA carboxylase
is catalyze to first phase of fatty acid biosynthesis and it synthesizes the palmitic acid.
It has been previously observed that a single bout of exercise increases phosphorylated acetyl-CoA carboxylase
(p-ACC) in the liver of mice and rats (4).