carboxyhaemoglobin


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car·box·y·he·mo·glo·bin

(kahr-bok'sē-hē'mŏ-glō'bin)
A stable union of carbon monoxide with hemoglobin. The formation of carboxyhemoglobin prevents the normal transfer of carbon dioxide and oxygen during the circulation of blood; thus, increasing levels of carboxyhemoglobin result in various degrees of asphyxiation, including death.
Synonym(s): carbon monoxide hemoglobin, carboxyhaemoglobin.

carboxyhaemoglobin

The stable compound formed between CARBON MONOXIDE and HAEMOGLOBIN that does not readily dissociate. As a result, the oxygen carrying power of the blood is limited. A high level of carboxyhaemoglobin is the cause of death in carbon monoxide poisoning as from car exhaust.

carboxyhaemoglobin

a stable compound produced when carbon monoxide combines irreversibly with HAEMOGLOBIN in the red blood cells, giving the blood a bright red colour. A consequence of the reaction is that haemoglobin is less able to combine freely with oxygen. This can lead to poisoning by lack of oxygen in the blood and eventually death if there is sufficient carbon monoxide in the atmosphere.
References in periodicals archive ?
This study was a cross-sectional comparative study which involved the assessment of carboxyhaemoglobin (% COHb) levels among traders in three motor parks and nonmotor park traders in Ibadan, Nigeria.
Russell, "Carboxyhaemoglobin and plasma thiocyanate: complementary indicators of smoking behaviour?," Thorax, vol.
The level of CO is an indirect measure of blood carboxyhaemoglobin (COHb).
The breath CO analyser is an instrument which calculates the amount of carbon monoxide in a single exhaled breath, automatically calculates the percentage of carboxyhaemoglobin in the blood of the mother and estimates the carboxyhaemoglobin in the baby's blood.
Dr Kazim explained that after carbon monoxide is breathed in, it enters your bloodstream and attaches to haemoglobin (the part of red blood cells that carry oxygen around your body), to form carboxyhaemoglobin.
Carbon monoxide is responsible for this as it raises the blood level of carboxyhaemoglobin, as well as nicotine and other compounds reducing the flow of blood in the foetus.
CO poisoning could not be excluded because of laboratory and transit errors, preventing a carboxyhaemoglobin level from being obtained.
Kevin, who was diagnosed as morbidly obese in May 2011, had a carboxyhaemoglobin level of 59% against a fatal level of 50%.
Furthermore, high affinity of CO for hemoglobin to form carboxyhaemoglobin is assumed as main attributor of CO toxicity causing acute poisoning leading to death [24, 27-31].
Roughton, "The kinetics of dissociation of the first ligand molecule from fully saturated carboxyhaemoglobin and nitric oxide haemoglobin in sheep blood solutions," Proceedings of the Royal Society of London B: Biological Sciences, vol.
According to forensic experts, a lethal dose of carboxyhaemoglobin was found in their blood.