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a platinum coordination compound that interferes with functioning of cellular DNA; used as an antineoplastic agent to treat cancers of the ovary, lung, head and neck, testes, bladder, brain, and other organs.


Pharmacologic class: Alkylating agent

Therapeutic class: Antineoplastic

Pregnancy risk category D

FDA Box Warning

• Give under supervision of physician experienced in cancer chemotherapy, in facility with adequate diagnostic and treatment resources.

• Bone marrow suppression is dose-related and may be severe, resulting in infection and bleeding. Anemia may be cumulative and warrant transfusions.

• Vomiting is a common adverse effect.

• Anaphylactic-like reactions may occur within minutes of administration.


Inhibits DNA synthesis by causing cross-linking of parent DNA strands; interferes with RNA transcription, causing growth imbalance that leads to cell death. Cell-cycle-phase nonspecific.


Injection: 50-mg, 150-mg, and 450-mg vials

Indications and dosages

Initial treatment of advanced ovarian cancer or palliative treatment of ovarian cancer unresponsive to other chemotherapeutic modalities

Adults: Initially, 300 mg/m2 I.V. (given with cyclophosphamide) at 4-week intervals. For refractory tumors, 360 mg/m2 I.V. as a single dose; may be repeated at 4-week intervals, depending on response. However, single dose shouldn't be repeated until neutrophil count is at least 2,000/mm3 and platelet count at least 100,000/mm3. Subsequent dosages are based on blood counts.

Dosage adjustment

• Renal impairment

• Reduced bone marrow reserve

Off-label uses

• Advanced endometrial cancer

• Advanced or recurrent squamous cell carcinoma of head and neck

• Relapsed and refractory acute leukemia

• Small-cell lung cancer

• Testicular cancer


• Hypersensitivity to drug, cisplatin, or mannitol

• Pregnancy or breastfeeding


Use cautiously in:

• hearing loss, electrolyte imbalances, renal impairment, active infections, diminished bone marrow reserve

• females of childbearing age.


• Premedicate with antiemetics, as prescribed.

• When preparing and administering drug, follow facility protocol for handling cytotoxic drugs.

• Reconstitute powder for injection by adding sterile water for injection, 0.9% sodium chloride injection, or 5% dextrose injection, as appropriate, to provide 10-mg/ml solution. Drug may be further diluted to concentrations as low as 0.5 mg/ml.

• Don't use with needles or I.V. sets containing aluminum.

• Administer I.V. infusion over at least 15 minutes.

• Make sure patient maintains adequate fluid intake.

• Know that drug is given in combination with other agents.

Adverse reactions

CNS: weakness, dizziness, confusion, peripheral neuropathy, cerebrovascular accident

CV: heart failure, embolism

EENT: visual disturbances, ototoxicity

GI: nausea, vomiting, constipation, diarrhea, abdominal pain, stomatitis

GU: gonadal suppression, nephrotoxicity

Hematologic: anemia, leukopenia, thrombocytopenia, neutropenia Hepatic: hepatitis

Metabolic: hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia

Respiratory: bronchospasm

Skin: alopecia, rash, urticaria, erythema, pruritus

Other: altered taste, hypersensitivity reactions, anaphylaxis


Drug-drug. Live-virus vaccines: decreased antibody response to vaccine, increased risk of adverse reactions

Myelosuppressants: additive bone marrow depression

Nephrotoxic or ototoxic drugs (such as aminoglycosides, loop diuretics): additive nephrotoxicity or ototoxicity

Phenytoin: decreased phenytoin blood level

Drug-diagnostic tests. Alkaline phosphatase (ALP), aspartate aminotransferase (AST), blood urea nitrogen, creatinine: increased values

Electrolytes, hematocrit, hemoglobin. neutrophils, platelets, red blood cells, white blood cells: decreased values

Patient monitoring

• Assess for signs and symptoms of hypersensitivity reactions.

• Monitor CBC to help detect drug-induced anemia and other hematologic reactions.

• Monitor ALP, AST, and total bilirubin levels.

• Evaluate fluid and electrolyte balance.

Patient teaching

• Instruct patient to report signs and symptoms of allergic response and other adverse reactions, such as breathing problems, mouth sores, rash, itching, and reddened skin.

• Advise patient to report unusual bleeding or bruising.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Urge patient to avoid activities that can cause injury. Advise him to use soft toothbrush and electric razor to avoid gum and skin injury.

• Instruct patient to drink plenty of fluids to ensure adequate urinary output.

• Provide dietary counseling and refer patient to dietitian as needed if GI adverse effects significantly limit food intake.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.


A platinum-containing anticancer agent much like cisplatin but more toxic to the myeloid elements of bone marrow while producing less nausea and neuro-, oto-, and nephrotoxicity; used in the chemotherapy of solid tumors.


/car·bo·pla·tin/ (kahr´bo-plat″in) an antineoplastic used in the treatment of carcinomas of the ovary and numerous other organs.


A platinum-containing chemotherapeutic drug used primarily in the treatment of advanced ovarian cancer.


one of a series of platinum analog drugs used in cancer therapy. It is commonly administered intravenously for the treatment of ovarian cancer.


A chemotherapeutic agent used to manage advanced ovarian, lung, head and neck and other cancers; it interacts with DNA in a manner similar to that of alkylating agents.

Adverse effects
Myelosuppression, nausea, vomiting diarrhoea, hair loss, pain, neurologic complaints.


Oncology A chemotherapeutic for advanced ovarian and other CAs Adverse effects Cytopenias, nausea, diarrhea, hair loss, pain, neurologic complaints


A platinum-containing anticancer agent much like cisplatin but more toxic to the myeloid elements of bone marrow while producing less nausea and neuro-,oto-, and nephrotoxicity; used in the chemotherapy of solid tumors.


An anticancer drug. A brand name is Paraplatin.


a cisplatin analog, but with fewer side-effects. Under investigation in the treatment of cancer in dogs. Myelosuppression limits the dose that can be used.
References in periodicals archive ?
Phase 2 trial of TI-CE high dose chemotherapy (HDCT) with drug monitoring for individual carboplatin dosing in patients with relapsed advanced germ cell tumours: A multicentric prospective GETUG trial.
This observation study was designed with the primary aim of comparing the efficacy and safety of cisplatin and carboplatin in patients with oral cancers, and it was observed that there was no significant difference in the efficacy between both the drugs, but there was an increase in the adverse effects in the cisplatin group when compared with the carboplatin group.
5 1 ml was drawn by cardiac puncture12 under light ether anesthesia on day 0 (before carboplatin injection) 7 14 and 21.
That compares with 48 percent of patients in the chemotherapy plus carboplatin group, 51 percent those in the chemotherapy plus Avastin group, and 61 percent of those in the chemotherapy plus carboplatin and Avastin group.
Lower incidence of second malignancies with carboplatin may be advantageous.
7 months for women treated with combination docetaxel and carboplatin therapy, vs.
Giving patients a carboplatin injection is less unpleasant with fewer longterm risks.
The new research reported that in men with surgically resected stage 1 seminoma, a single dose of carboplatin chemotherapy is as effective as two to three weeks of radiation therapy in preventing recurrence and is much less toxic.
Patients with ovarian cancer who have a hypersensitivity reaction to carboplatin can be successfully treated with cisplatin without a lengthy desensitization procedure, Dr.
The FDA has approved the use of Avastin (bevacizumab) in combination with carboplatin and paclitaxel for the initial systemic treatment of patients with unresectable, locally advanced, recurrent or metastatic, non-squamous, non-small cell lung cancer.