carbonic anhydrase inhibitors


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to carbonic anhydrase inhibitors: acetazolamide

carbonic anhydrase inhibitors

A class of drug that act by blocking the action of the enzyme CARBONIC ANHYDRASE. This enzyme greatly speeds up the reaction between carbon dioxide and water to form carbonic acid, a compound needed for the production of many of the body's secretions. Carbonic anhydrase is present in high concentration in the eye, the kidneys, stomach lining and pancreas. Inhibitor drugs reduce the rate of secretion of aqueous humour in the eye and is useful in treating GLAUCOMA. These drugs are also valuable in treating mountain sickness, periodic paralysis and absence attacks (petit mal). The group includes ACETAZOLAMIDE and DORZOLAMIDE.

carbonic anhydrase inhibitors 

Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.
References in periodicals archive ?
c) Alpha adrenergic agonists and carbonic anhydrase inhibitors may not be effective at reducing IOP sufficiently
These results are consistent with the results obtained through the study carried out by Pichake et al., 2014, [58] in order to evaluate human carbonic anhydrase inhibitors. In this study importance of nature of substitution on para position was discussed.
Osmotic diuretics (like mannitol) and carbonic anhydrase inhibitors (like acetazolamide) produce an opposite effect comparing to the majority of the other diuretics, decreasing lithium concentration (being therefore classically used to treat lithium's intoxication).
Supuran, "Glaucoma and the applications of carbonic anhydrase inhibitors," in Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications, vol.
Decreased macular thickness in nonproliferative macular telangiectasia type 2 with oral carbonic anhydrase inhibitors. Retina.
Browse Glaucoma Therapeutics Market by Drug Class (Alpha Agonist, Beta Blockers, Carbonic Anhydrase Inhibitor, Cholinergic, Combined Medication, Prostaglandin Analogs), End Users (Ambulatory Surgical Centers, Hospitals, Ophthalmic Clinics) and Forecast 2017-2021 at https://www.ihealthcareanalyst.com/report/glaucoma-therapeutics-market/
The different groups of drugs prescribed were P-blockers (41.66%), prostaglandin analogs (33.33%), [[alpha].sub.2] adrenergic receptor agonist (16.66%), and carbonic anhydrase inhibitors (08.33%) Figure 1.
One is to promote uveoscleral outflow, such as prostaglandin (PG) analogs, [alpha][beta]-adrenergic receptor blockers, a1-adrenergic receptor blockers, and a2-adrenergic receptor agonists, and the other is to suppress aqueous humor production, such as [beta]-adrenergic receptor blockers, carbonic anhydrase inhibitors (CAI), and [alpha][beta]-adrenergic receptor blockers [23].
Supuran, "Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions," Bioorganic and Medicinal Chemistry Letters, vol.
Case 4###72###Male###Right###Beta blocker, , alpha agonist, Carbonic anhydrase inhibitors, Prostaglandin analouge
Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression.
Control of intracranial pressure is done with medical therapy like carbonic anhydrase inhibitors, antiplatelets and high dose steroids.

Full browser ?