CA.1bc.12

(redirected from carbonic anhydrase XII)

CA.1bc.12

A gene on chromosome 15q22 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. The CA12 product is a type-I membrane protein which is highly expressed in normal tissues, such as the kidneys, colon and pancreas.

Molecular pathology
CA12 is overexpressed in 10% of clear-cell carcinomas of the kidney.
References in periodicals archive ?
Charn et al., "Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer," Cancer Research, vol.
Hsieh, "Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway," European Journal of Cell Biology, vol.
Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium.
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