CA.1aj.9

(redirected from carbonic anhydrase IX)

CA.1aj.9

A gene on chromosome 9p12 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. CA9 is a transmembrane protein and the only known tumour-associated carbonic anhydrase isoenzyme, and may be involved in cell proliferation and transformation.

Molecular pathology
CA9 is expressed in all clear-cell type renal cell carcinomas, but is not expressed in normal kidney or most other normal tissues.
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An immunocytochemical (ICC) panel including thyroid transcription factor 1 (TTF-1) and thyroglobulin (thyroid markers) combined with CD10, RCC antigen, and carbonic anhydrase IX (CAIX) (RCC markers) has been suggested to help in such cases.
Metastases to the Thyroid: Potential Cytologic Mimics of Primary Thyroid Neoplasms
Rafajova et al., "Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH," FEBS Letters, vol.
Electric Cell-Substrate Impedance Sensing of Cellular Effects under Hypoxic Conditions and Carbonic Anhydrase Inhibition
Socorro et al., "The structure of carbonic anhydrase IX is adapted for low-pH catalysis," Biochemistry, vol.
Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors
Carbonic anhydrase IX (CAIX) is a transmembrane protein that catalyzes the hydration of carbon dioxide to carbonic acid, modulating pH [20].
Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation
The expression of carbonic anhydrase IX (CA IX) and vascular endothelial growth factor (VEGF) was analyzed by immunohistochemistry.
Blood Oxygenation Level-dependent Magnetic Resonance Imaging of Breast Cancer: Correlation with Carbonic Anhydrase IX and Vascular Endothelial Growth Factor
In this context, blocking carbonic anhydrase IX, which is specifically upregulated by hypoxia in tumors and participates in tumor progression, represents a promising approach [103].
Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity
Supuran, Carbonic Anhydrase IX: A New Druggable Target for the Design of Antitumor Agents, Med.
Synthetic N-Aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As Potent Anti-Bacterial Agents
Objective: In this study, we evaluated the prognostic value of carbonic anhydrase IX (CA9) and HIF-la and their relations with anatomic.
Renal hucreli karsinomda karbonik anhidraz 9 ve HIF-l[alpha]'nin prognostik degeri / Prognostic value of carbonic anhydrase IX and HIF-l[alpha] in renal cell carcinoma
Carbonic anhydrase IX (CAIX), plasmatic VEGF level, hypoxia-inducible factor-2-alpha (HIF-2-a) expression, phospho-S6, and phospho-AKT have been reported to be predictive markers of the efficacy of different agents and should be investigated to determine the optimal course of therapy (36, 37).
Renal cell carcinoma: molecularly targeted therapy
A potential tumor marker for RCC is a screen for serum carbonic anhydrase IX (CAIX).
Metastatic renal cell carcinoma with metabolic syndrome- a case report
Tumor levels of a third tumor protein regulated by HIF-1alpha, carbonic anhydrase IX (CA IX), were also decreased, consistent with HIF-1alpha inhibition.
FDA ACCEPTS ENTREMED IND FOR ENMD-1198 ANTITUMOR AGENT
Laferriere et al., "Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH," Cancer Research, vol.
Crystallography and Its Impact on Carbonic Anhydrase Research

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