CA.1aj.9

(redirected from carbonic anhydrase IX)

CA.1aj.9

A gene on chromosome 9p12 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. CA9 is a transmembrane protein and the only known tumour-associated carbonic anhydrase isoenzyme, and may be involved in cell proliferation and transformation.

Molecular pathology
CA9 is expressed in all clear-cell type renal cell carcinomas, but is not expressed in normal kidney or most other normal tissues.
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An immunocytochemical (ICC) panel including thyroid transcription factor 1 (TTF-1) and thyroglobulin (thyroid markers) combined with CD10, RCC antigen, and carbonic anhydrase IX (CAIX) (RCC markers) has been suggested to help in such cases.
Rafajova et al., "Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH," FEBS Letters, vol.
Socorro et al., "The structure of carbonic anhydrase IX is adapted for low-pH catalysis," Biochemistry, vol.
Carbonic anhydrase IX (CAIX) is a transmembrane protein that catalyzes the hydration of carbon dioxide to carbonic acid, modulating pH [20].
The expression of carbonic anhydrase IX (CA IX) and vascular endothelial growth factor (VEGF) was analyzed by immunohistochemistry.
In this context, blocking carbonic anhydrase IX, which is specifically upregulated by hypoxia in tumors and participates in tumor progression, represents a promising approach [103].
Supuran, Carbonic Anhydrase IX: A New Druggable Target for the Design of Antitumor Agents, Med.
Objective: In this study, we evaluated the prognostic value of carbonic anhydrase IX (CA9) and HIF-la and their relations with anatomic.
Carbonic anhydrase IX (CAIX), plasmatic VEGF level, hypoxia-inducible factor-2-alpha (HIF-2-a) expression, phospho-S6, and phospho-AKT have been reported to be predictive markers of the efficacy of different agents and should be investigated to determine the optimal course of therapy (36, 37).
A potential tumor marker for RCC is a screen for serum carbonic anhydrase IX (CAIX).
Tumor levels of a third tumor protein regulated by HIF-1alpha, carbonic anhydrase IX (CA IX), were also decreased, consistent with HIF-1alpha inhibition.
Laferriere et al., "Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH," Cancer Research, vol.

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