CA.1bc.12

(redirected from carbonic anhydrase 12)

CA.1bc.12

A gene on chromosome 15q22 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. The CA12 product is a type-I membrane protein which is highly expressed in normal tissues, such as the kidneys, colon and pancreas.

Molecular pathology
CA12 is overexpressed in 10% of clear-cell carcinomas of the kidney.
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References in periodicals archive ?
NPPC and carbonic anhydrase 12 (CA12) were validated as Gen-induced genes, and interestingly, Dex antagonized Gen-induction for both genes.
(B) mRNA expression of CA12 (carbonic anhydrase 12; top), LEFTY1 (left-right determination factor 1; center), and GILZ (glucocorticoid-induced leucine zipper; bottom) in cells pretreated 1 hr with ICI (left) or RU486 (RU; right) and then treated with vehicle (Veh), Dex, Gen, or Dex + Gen for 6 hr.