Antifungal activities of 10-(H)-acridin-9-one carbohydrazides 7-27 were determined against seven fungal species Aspergillus flavus, Aspergillus niger, Penicillium spp, Rhizopus spp, Candida albicans, Saccharomyces cerevisiae and Candida tropicalis and compared with standard drugs ketacanazole.
Table-3: Antibacterial activity (In vitro) of 10-(H)-acridin-9-one carbohydrazides 7-27 against Gram-negative bacteria
Table-4: Antifungal activity (in vitro) of 10-(H)-acridin-9-one carbohydrazides 7-27.
Antimicrobial activities of 10-(H)-acridin-9-one carbohydrazides against different bacterial and fungal strains were determined by disc diffusion method.
Synthesis of acridone carbohydrazide proceeds in five steps.
Synthetic 10-(H)-acridin-9-one carbohydrazide analogs (7-27) were tested against different bacterial strains including nine Gram-positive species methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus, Corynebacterium diphtheria, Staphylococcus epidermidis, Staphylococcus saprophyticus, Corynebacterium xerosis, Streptococcus pyogene and eleven Gram-negative species Enterobacter, Escherichia coli, E.
Two p-substituted carboxylic acids (1a and 1b) have been utilized to synthesize ethyl esters (2a and 2b), carbohydrazides
(3a and 3b), 5-substituted-1,3,4-oxadiazol-2-thiols (4a and 4b), heterocyclic ethyl esters (5a and 5b) and finally acetohydrazides (6a and 6b).