carbidopa


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to carbidopa: Entacapone

carbidopa

 [kahr-bĭ-do´pah]
an inhibitor of the decarboxylation of levodopa in peripheral tissues; it does not cross the blood-brain barrier and is used in combination with levodopa to control the symptoms of parkinson's disease. In the presence of carbidopa, levodopa enters the brain in larger quantities, thus avoiding the need for excessively high doses of levodopa.

car·bi·do·pa

(kar'bi-dō'pă),
A dopa decarboxylase inhibitor that does not enter the brain used in conjunction with levodopa in the treatment of Parkinson disease to reduce L-dopa dosage and mitigate side effects.

carbidopa

(kär′bĭ-dō′pə)
n.
A drug, C10H14N2O4, that increases the availability of L-dopa to the brain and is administered with L-dopa to treat Parkinson's disease.

car·bi·do·pa

(kahr'bi-dō'pă)
A dopa decarboxylase inhibitor that does not enter the brain used in conjunction with levodopa in the treatment of parkinsonism to reduce L-dopa dosage and mitigate side effects.

carbidopa

A drug that prevents the breakdown of the drug levodopa in the body and thus enhances its action in PARKINSON'S DISEASE. See also BENSERAZIDE. A brand name is Sinemet.
References in periodicals archive ?
"Carbidopa is an FDA-approved drug for treating Parkinson's disease.
The death rate in Parkinson's patients has increased by 328.7% between 1976 and 2011, when carbidopa was first introduced.
The unique design of this trial should allow us to not only explore the role and potential therapeutic application of norepinephrine in fibromyalgia, but, by pairing droxidopa with carbidopa to limit peripheral metabolism of droxidopa into norepinephrine, should also allow us to more closely examine the central effect of NE in this indication."
Mohaddesi pointed out to another finding in this research, and said, "The use of carbon nanotube showed desirable results in the measurement of carbidopa at very low concentrations.
"If you have any doubts about whether this is RLS or not RLS, you can use the levodopa"-carbidopa combination (carbidopa 25 mg/levodopa 100 mg) of 1/2-1 1/2 tablets for 3 days.
In the spring Mylan received approval from the Food and Drug Administration to manufacture and market carbidopa and levodopa extended-release tablets in 25 mg./ 100 mg.
M2 EQUITYBITES-July 20, 2017-Intec Pharma awarded patent for Accordion Pill Carbidopa / Levodopa in Hong Kong
DRUG DOSAGE COST/DAY [*] DOPAMINE PRECURSOR carbidopa and Start at 25 mg of carbidopa $1.86 (75 mg levodopa and 100 mg of levodopa and 300 mg per t.i.d.; maximum dosage is day) 200 mg and 800 mg per day carbidopa and 50 mg of carbidopa and 200 $3.16 (100 mg levodopa mg of levodopa b.i.d.; and 400 mg per controlled-release maximum dose is 400 mg and day) (Sinemet CR) 1,600 mg per day DOPAMINE AGOINSTS bromocriptine Start with 2.5 mg/day; final $3.34 (5 mg) dose is usually 5-7.5 mg/day pergolide Start with 0.05 mg/day; $3.70 (1 mg) (Permax) maximum of 5 mg/day pramipexole Start with 0.125 mg t.i.d.; $5.49 (1 mg (Mirapex) maximum of 1.5 mg t.i.d.