carbenoxolone


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carbenoxolone

A drug used to promote healing in stomach and duodenal ulcers. A brand name is Bioplex. Formulated with magnesium trisilicate it is marketed as Pyrogastrone.
References in periodicals archive ?
Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson's disease.
2,599 items of experiments involved in drug testing protocols ((2R)-amino-5-phosphonovaleric acid (APV), bicuculline (BIC), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), tetrodotoxin (TTX), octanol (OCT), carbenoxolone (CBX), brain-derived neurotrophic factor (BDNF), etc.).
(11) Carbenoxolone, a hemi-succinate ester of glycyrrhizic acid which has been synthetically produced from liquorice, also has this action.
This ATP release was Panx1 channel-mediated as shown by the prevention of ATP release with pharmacological inhibitors, such as carbenoxolone (CBX) or [10] Panx, and with siRNA-mediated knockdown of Panx1.
Several HSF-1 modulators including celastrol and carbenoxolone can trigger HSF-1 activation, leading to downstream induction of Hsp70 expression [9] (Figure 1).
The mice were divided into different groups (n = 6) and pretreated orally with vehicle (water, 10mL/kg), carbenoxolone (used as the positive control, 100mg/kg), MEMN (30-300mg/kg), or MERN (10-300 mg/kg); an ulcerogenic solution composed of 60% ethanol/0.3M HCl was orally given to the mice one hour after the pretreatments [19].
Carbenoxolone (CBX) is a synthetic GL derivative that abrogated lipopolysaccharide- (LPS-) induced HMGB1 release in macrophage cultures by impairing PKR activation [167].
Effects of carbenoxolone in lean and obese Zucker rats," Journal of Pharmacology and Experimental Therapeutics, vol.
In order to measure the effect of gap junction blockers on [H.sub.2][O.sub.2]-induced cell death, gap junction Cx43 blocker carbenoxolone (Cbx) at the concentration of 100 [micro]M was added 30 min earlier before [H.sub.2][O.sub.2] treatment.
W., Colin Jones D.G., Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.