Of great concern is the over-use of carbapenems
in hospitals for treating Gram-negative bacterial infections, which is contributing to the increasing emergence of carbapenem
However, ESBLs and AmpC can confer carbapenem
resistance when associated with alteration or loss of porins, a family of proteins on the outer membrane of gram-negative bacteria (2,5).
5,14] Previous studies from Turkey have reported 55-70% carbapenem
resistance for A.
Non-plasmid mediated carbapenem
resistance, while serious, is not as easily transferrable, although treatment of the infected patient and infection control are important regardless of CRE mechanism.
A second carbapenem
resistance gene, NDM-1, was identified in 2006 in New Delhi, India.
The publication of the toolkit on how to manage a particular type of antibiotic resistant bacteria called carbapenemase-producing Enterobacteriaceae which is an area of concern as bacteria with this mechanism are resistant to carbapenem
antibiotics which are those usually used as last resort .
According to the researchers "AMA, extracted from a strain of Aspergillus versicolor and combined with a carbapenem
antibiotic, inactivated the NDM-1 gene in three drug-resistant superbugs-Enterobacteriaceae, a group of bacteria that includes E.
Guidance for control of carbapenem
resistant Enterobacteriaceae (CRE).
According to the report, resistance to the treatment of last resort for life- threatening infections caused by a common intestinal bacteria, Klebsiella pneumonia -- carbapenem
antibiotics -- has spread to the entire world.
Key findings from the report included that resistance to the treatment of last resort for life-threatening infections caused by a common intestinal bacteria, Klebsiella pneumoniae carbapenem
antibiotics has spread to all regions of the world.
Prof Neil Woodford, of Public Health England, said: "KPC is one of a number of enzymes that can make a bacteria resistant to carbapenem
are potent agents for the treatment of this pathogen.