This hypothesis is supported by expression of arcA, arcB, arcC, and arcD, genes predicted to encode an arginine deiminase, an ornithine
carbamoyltransferase, a carbamate kinase, and an arginine/ornithine antiporter, respectively (Table 3).
Nearly all of the proteins altered in significant amounts were identified as enzymes associated with important metabolic pathways, such as alcohol dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Xaa-His dipeptidase, ornithine
carbamoyltransferase, putative O-acetylserine lyase, enolase (2-phosphoglycerate dehydratase), fructose-bisphosphate aldolase, and cysteine synthase.
7] Human genes: CPS1, carbamoyl-phosphate synthetase 1, mitochondrial; NAGS, N-acetylglutamate synthase; OTC, ornithine
carbamoyltransferase.
Tamir and Ratner (1963) attributed birds' incapacity to synthesize ornithine, citrulline and Arg to the absence of another enzyme key to the urea cycle, ornithine
carbamoyltransferase (Figure 2).
2
carbamoyltransferase Phosphoenolpyruvate NM_174737.
This dramatic case stumped physicians until the woman's blood revealed a telltale high level of ammonia, a diagnostic clue suggesting a rare, inherited disorder called ornithine
carbamoyltransferase deficiency.
One of the girls who died after dermal exposure was partially deficient in the enzyme ornithine
carbamoyltransferase (3); DEET may interfere with the urea cycle metabolic pathway (10).
Mutation detection in 65 families with a possible diagnosis of ornithine
carbamoyltransferase deficiency including 14 novel mutations.
The genes surrounding the GK gene, from telomere to centromere, are Xpter-interleukin 1 receptor accessory protein-like 1 (IL1RAPL1); nuclear receptor subfamily 0, group B, member 1 (NR0B1); GK, dystropin (DMD); and ornithine
carbamoyltransferase (OTC)-cent.
Ornithine
carbamoyltransferase deficiency: improved sensitivity of testing for protein tolerance in the diagnosis of heterozygotes.
liver-type arginase (ARG), ornithine
carbamoyltransferase (OCT), and argininosuccinate synthase (AS), exist almost exclusively in the liver (1-3) and may serve as more specific markers of liver injury.
X-linked ornithine
carbamoyltransferase (OCT; EC 2.
