capsular switching

capsular switching

A change in the polysaccharide capsule that encloses a bacterium, typically as a result of gene transfer between related organisms. It alters the susceptibility of encapsulated bacteria (such as meningococci and pneumococci) to antibiotic therapy.
References in periodicals archive ?
Capsular Switching and Other Large-Scale Recombination Events in Invasive Sequence Type 1 Group B Streptococcus
The case of a new sequence type 7 serogroup X Neisseria meningitidis infection in China: may capsular switching change serogroup profile?
Mechanisms for changes in serotype prevalence include serotype replacement and capsular switching (genetic serotype switch in individual organisms) (14).
Capsular switching in group B Streptococcus CC17 hypervirulent clone: a future challenge for polysaccharide vaccine development.
Recombination leading to capsular switching has been reported numerous times in GBS (3, 6, 8).
So-called capsular switching might have contributed to increasing non-PCV7 serotype disease (28).
meningitidis core genome amino acid sequences showed that all 22 sequenced CC4821 strains were closely related, irrespective of serogroup, ST, and PorA type, which indicated capsular switching between serogroups C and B.
However, this association could be disrupted because of capsular switching caused mainly by recombination of capsular genetic loci.
Capsular switching also is associated with recombination of PBP genes, considering that pbp1a and pbp2x genes which mediate [beta]-lactam resistance, are positioned at both ends of the cps region.
Capsular switching has been observed among pneumococcal serotypes after the 7-valent pneumococcal conjugate vaccine was introduced in the United States, although the substantial declines in incidence of pneumococcal disease were maintained overall (25).
Some of these clones, namely, cc11 and cc32, have undergone capsular switching.
Capsular switching, which occurs through transformation and horizontal gene transfer, enables N.