capsaicin


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capsicum

 [kap´sĭ-kum]
a plant of the genus Capsicum, the hot peppers, or the dried fruit derived from certain of its species (cayenne or red pepper); it contains the active ingredient capsaicin and is used as a counterirritant and also in pepper spray.

cap·sa·i·cin

(kap-sā'i-sin),
Alkaloidal principle in the fruits of various species of Capsicum, with the same uses. It depletes substance P from sensory nerve endings; sometimes used for pain in postherpetic neuralgia.

capsaicin

(kăp-sā′ĭ-sĭn)
n.
A pungent alkaloid, C18H27NO3, derived from certain capsicums that is a strong irritant to skin and mucous membranes and is used in some topical pain relievers and in pepper sprays.
Alternative nutrition A nutraceutical or food component from hot pepper that may prevent or mitigate disease and which may block pain signals
Source Chilli peppers
Neurology Capsaicine A chemical from hot chilli peppers that may be used in managing painful dysesthaesias of herpes and diabestes
Management Casein, a lipophilic phosphoprotein, acts like a detergent and strips the capsaicin from the receptors in the oral cavity

capsaicin

Neurology Capsaicine A chemical from red hot chili peppers that may be used for painful dysesthesias of herpes and DM; topical capsaicin triggers release of the neuropeptide, substance P from type C nociceptive fibers, opens Ca2+ and Na+ channels causing the initial pain associated with 'hot' foods; substance P is not replenished, thus pain sensation is ↓ after the initial pain; capsaicin binding is relatively strong and attributed to its lipophilic side chain Management Casein, a lipophyilic phosphoprotein acts like a detergent and strips the capsaicin from the receptors in the oral cavity; topical capsaicin may ↓ the symptoms of painful diabetic neuropathy. See Blister beetle, Scoville unit, Spicy foods.

cap·si·cum

(kap'si-kŭm)
Dried herbal remedy (and spice) made from Capsicum frutescens and other Capsicum spp.; both internal and external medicinal uses have been described (e.g., analgesic, therapy for GU problems).
Synonym(s): capsaicin, cayenne, hot pepper, red pepper.
[L., fr. capsa, box, case]

capsaicin

A pain-killing drug for external application used in the treatment of post-shingles pain and other painful peripheral nerve disorders. Brand names are Axsain and Zacin.

Capsaicin

An alkaloid found in hot peppers that is used in an inhalation test to identify patients with MCS.

cap·sa·i·cin

(kap-sā'i-sin)
Alkaloid used for analgesia.
[Irreg. fr. capsicum, + -in]
References in periodicals archive ?
In this study, we investigated the antimicrobial activity of capsaicin against the growth and biofilm formation of Streptococcus mutans, Actinomyces viscosus, Lactobacillus and Streptococcus sanguis, to expect to provide a promising method and idea for clinical caries prevention.
Additional experiments revealed that capsaicin suppresses lung cancer metastasis by inhibiting the activation of the protein Src.
They also found mice with metastatic cancer that consumed capsaicin showed smaller areas of metastatic cancer cells in the lung compared with mice not receiving the treatment.
Concentrate of capsaicin is a component of pepper sprays now used by some security forces, and a full blast in the face will render the receiver immobile for up to ten minutes.
Applied to the area of pain, the capsaicin reduces the spontaneous activity and consequently reduces the neuropathic pain intensity.
Guidelines published in March 2018 in the Western Journal of Emergency Medicine, written by LaPont et al, describe how capsaicin is used to treat CHS:
In reduced doses, capsaicin can relieve pain as well.
Meta-analyses and systematic reviews have shown capsaicin is effective for various painful conditions, including peripheral diabetic neuropathy, OA, and PHN.
The strong and sometimes overwhelming effects that come with eating spicy food are caused by one small chemical found in chili peppers: capsaicin. The discomfort of eating high amounts of capsaicin is meant to deter overconsumption, but for those able to overcome both the physical and mental pain, the consequences can range from unpleasant to just plain deadly.
Capsaicin, a medicinally-active component of chilli peppers, is licensed in the UK for osteoarthritis.
Therefore, our contribution presents data on possible effective treatments to mitigate acute effects: the use of haloperidol and capsaicin.