capreomycin


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capreomycin

 [kap″re-o-mi´sin]
a polypeptide antibiotic produced by Streptomyces capreolus, which is active against human strains of Mycobacterium tuberculosis; used as the disulfate salt.

capreomycin

/cap·reo·my·cin/ (kap″re-o-mi´sin) a polypeptide antibiotic produced by Streptomyces capreolus, which is active against human strains of Mycobacterium tuberculosis ; used as the disulfate salt.

capreomycin

(kăp′rē-ō-mī′sĭn)
n.
An antibiotic that is derived from a bacterium (Streptomyces capreolus) and is used in its sulfate form to treat tuberculosis.

capreomycin

[kap′rē·ōmī′sin]
an antibiotic and antitubercular agent.
indications It is prescribed in the treatment of pulmonary infections caused by capreomycin-susceptible strains of Mycobacterium tuberculosis when the primary agents are ineffective or cannot be used.
contraindications Known sensitivity to this drug prohibits its use. It must be used with caution in patients with preexisting renal or auditory impairment.
adverse effects Among the most serious adverse reactions are nephrotoxicity, hearing loss, tinnitus, vertigo, leukocytosis, leukopenia, urticaria, and skin rash.

capreomycin

An aminoglycoside-related cyclic peptide antibiotic used in combination with streptomycin and other agents to treat Mycobacterium avium complex and M tuberculosis.

Adverse effects
Nephrotoxicity, ototoxicity and hearing loss, anorexia, thirst, excess urination, haematuria, anaemia.

capreomycin

Infectious disease An antibiotic used to treat MAC and TB Side effects Anorexia, thirst, excess urination, hematuria, anemia, hearing loss. See AIDS.

capreomycin

An antibiotic drug derived from Streptomyces capreolus and used in the treatment of TUBERCULOSIS resistant to standard drugs such as RIFAMPICIN, ISONIAZID, ETHAMBUTOL and STREPTOMYCIN. The drug is on the WHO official list. A brand name is Capastat.
References in periodicals archive ?
MDR, KMRC 00116-00250, pathogenic-resistant to isoniazid, rifampicin, streptomycin, and pyrazinamide; XDR, KMRC 00203- 00197, pathogenic-resistant to isoniazid, rifampicin, ethambutol, kanamycin, ofloxacin, rifabutin and amikacin, but susceptible to capreomycin, streptomycin, moxifloxacin, prothionamide, p-aminosalicylic, and cycloserine.
Molecular genetics of Mycobacterium tuberculosis resistant to aminoglycosides and cyclic peptide capreomycin antibiotics in Korea.
The intensive phase of treatment with capreomycin should be at least 8 months (8)
45) In contrast, the method was not as sensitive for detecting resistance to kanamycin or ethambutol, and had a poor predictive value for detecting resistance to capreomycin.
Seeking yet another physician's care, she was offered another multidrug program, this time including the capreomycin that was not prescribed two years earlier.
tuberculosis have emerged which are resistant to at least the two most potent anti-TB drugs, INH and Rifampicin, in addition to any fluoroquinolone and to at least one of the injectable second-line drugs, Amikacin, Kanamycin, Viomycin and Capreomycin.
XDR-TB is a form of TB caused by bacteria that are resistant to most effective anti-TB drugs and defined as resistance to at least RIF and INH and to any member of the quinolone family and at least one of the following second-line anti-TB injectable aminoglycosides: kanamycin, capreomycin, or amikacin (8).
tuberculosis with resistance to isoniazid, and rifampin,any fluoroquinolones and at least three injectable second line drugs such as amikacin, capreomycin,or kanamycin.
In the intensive phase patients received the capreomycin or amikacin i/m, prothionamid or ethionamid, ofloxacin (levofloxacin, cycloserin, pyrazinamide and ethambutol when M.
20) When considering what to do in the light of this co-toxicity, it is important to recall that the aminoglycosides (kanamycin or amikacin) used in the treatment of MDR TB and the cyclic polypeptide, capreomycin, used in the treatment of extensively drug-resistant (XDR) TB, are essential components of these treatment regimens.
Extensively drug-resistant TB is defined as a form of TB caused by bacteria that are resistant to isoniazid and rifampicin as well as any fluoroquinolone and any of the second-line anti-TB injectable drugs such as amikacin or capreomycin.