Inhibitory effect of the extracts from Plantago lanceolate on acetic acid-induced increase in capillary permeability
Material Dose Evans blue concentration Inhibition (%) (mg/kg) (Lg/mL) [+ or -] SEM Control 9.62 [+ or -] 0.74 Aqueous extract 100 8.13 [+ or -] 0.45 15.49 200 7.02 [+ or -] 0.53 27.03 (*) MeOH extract 100 8.71 [+ or -] 0.33 9.46 200 7.24 [+ or -] 0.71 24.74 (*) Indomethacin 10 4.78 [+ or -] 0.27 50.31 (***) (*): p<0.05.
Experimental data showed that ERP (120-480 mg/kg) dose dependently attenuated the capillary permeability
accentuation induced by acetic acid in mice.
Other research could focus on the use of agents to reduce pulmonary capillary permeability
and provide membrane stabilization, such as corticosteroids, oxygen free-radical scavengers, and cyclo-oxygenase inhibitors.
(In medical jargon this is known as an increase in capillary permeability
.) Because of these dual actions, bleeding in an RU486 abortion usually remains profuse for days.
It combats capillary permeability
and fragility; it inhibits the clumping of blood; it lowers fat and cholesterol levels; it improves circulation and reduces cardiovascular abnormalities.
The venom enzyme, without an exogenous source of kininogen, did not cause an increase in capillary permeability
as determined by the Evans blue stain method.
Colloidal and crystalloidal fluid resuscitation in shock associated with increased capillary permeability
. Curr Stud Hematol Blood Transfus 1986; 53:86-100.
The tight junction (TJ) between cells is important for maintaining capillary permeability
. The intercellular gap is increased when the TJ is damaged by various causes, which may lead to the increase in vascular permeability (6).
Venoactive drugs decrease venous tone, thereby reducing capillary permeability
and the tendency to oedema.
Pulmonary edema is another critical issue of acute lung injury, which results from breathing membrane barrier (BBB) dysfunction, and capillary permeability
increase [18, 19].
It has been suggested that Pycnogenol may bind to the blood vessel wall proteins and mucopolysaccharides and produce a capillary 'sealing' effect, leading to a reduced capillary permeability
and oedema formation.