cap-binding protein


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cap-binding protein

A 24-kD protein with affinity for the cap structure at 5’ end of mRNA, which helps with other initiation factors. The cap-binding complex bind mRNA to the 40S ribosomal subunit; the cap-binding protein accelerates in vitro mRNA translation.
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References in periodicals archive ?
Cate, "eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation," Nature, vol.
Development of therapeutics targeting eIF4E2 is in their infancy as this cap-binding protein has only recently been linked to tumor growth and its mechanisms of initiation and regulation are only beginning to be elucidated.
Matta-Camacho et al., "Cap-binding protein 4EHP effects translation silencing by microRNAs," Proceedings of the National Academy of Sciences of the United States of America, vol.
Browning, "Identification and characterization of a novel cap-binding protein from Arabidopsis thaliana," The Journal of Biological Chemistry, vol.
(1988) Cap-binding proteins of eukaryotic mRNA: Functions in initiation and control of translation.
(2010) Cap and cap-binding proteins in the control of gene expression.
Usui et al., "A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E," Biochemical Journal, vol.