canyon hypothesis

canyon hypothesis

Virology
A theory that seeks to explain the relative resistance of some viruses; according to the CH, the canyon is possible site for virus-receptor binding present in rhinoviruses and picornaviruses, in which the target is bound while prohibiting anti-viral antibody interaction, as the canyon’s narrowness renders the pathogen inaccessible to the immune system.
References in periodicals archive ?
The canyon hypothesis. Hiding the host cell receptor attachment site on a viral surface from immune surveillance.