cantharidin


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cantharidin

 [kan-thar´ĭ-din]
the most active principle of cantharides, the dried Spanish fly, Lytta vesicatoria; preparations containing cantharidin are used topically as a vesicant to remove warts and lesions of molluscum contagiosum.

can·thar·i·din

(kan-thar'i-din),
The active principle of cantharis; the anhydride of cantharic acid.
Synonym(s): cantharis camphor

cantharidin

(kăn-thăr′ĭ-dĭn)
n.
A toxic compound, C10H12O4, that is found in blister beetles and is the active ingredient of Spanish fly.
The active component of Chinese fly and Cantharis—Spanish fly; it is highly irritating and causes vesicle formation; it has been used to treat warts and other skin lesions
References in periodicals archive ?
It is important to be careful when applying or handling cantharidin near the eyes, they noted.
It's reported that cantharidin causes patient's hematochezia and tenesmus.
However, knowledge about the role of cantharidin in anticancer activity is limited.
Yang, "Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells," Toxicology, vol.
Lee et al., "Cantharidin induces apoptosis through the calcium/PKC-regulated endoplasmic reticulum stress pathway in human bladder cancer cells," The American Journal of Chinese Medicine, vol.
Through previous studies, it is known that the Norcantharidin, a derivative of the Cantharidin, inhibits 1 [micro]M of PP5; however, it is not selective towards PP5.
Therefore, we have decided to examine cantharidin, a natural toxin that can induce apoptosis.
Effect of salicylic acid, methyl jasmonate, ethephon and cantharidin on anthraquinone production by Rubiacordifolia callus cultures transformed with the rolB and rolC genes.
Antitumor drugs like cantharidin control cell cycle and induce apoptosis by inhibiting PP2A [85], and cell viability inhibition and proapoptotic effect of cantharidin in PANC-1 pancreatic cancer is mediated by the PP2A/IkB kinase (IKK[alpha])/I[kappa]Ba/p65 NF-[kappa]B pathway [86].
maximum is unknown, but a previous research ruled out the possibility that the disease is caused by oxalates or saponins contained in the pasture or by contamination by Pithomyces chartarum or insects of the genus Epicauta producers of cantharidin (CERQUEIRA et al., 2009).
(viii) myosin light chain phosphatase, MLCP (dephos-phorylates MLC) [inhibitor cantharidin (3a,7a-dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione), 10 [micro]mol [1.sup.-1], diluted in DMS01 (Khattab et al., 2007).
Active treatment is used for cosmetic and epidemiologic reasons and includes curettage, cryotherapy, cantharidin, and topical imiquimod.