(39) Likewise, in another study, there was a pronounced association between a polymorphism in the cannabinoid receptor 1
(CNR1) gene and IBS symptoms, colonic transit in IBS-D, and intestinal gas.
The analgesic effects of cannabinoids and their ligands are primarily mediated by the cannabinoid receptor 1
(CB1) via inhibition of presynaptic gamma-aminobutyric acid (GABA) and glutamatergic transmission.
In 1988, Howlett's group (Devane et al., 1988) suggested the existence of a specific receptor for cannabinoids known as "cannabinoid receptor 1
" or CB1, which is mainly distributed throughout the central nervous system (Burns et al., 2007; Egertova, Giang, Cravatt & Elphick, 1998; van Laere et al., 2008).
Loss of cannabinoid receptor 1
accelerates intestinal tumour growth.
Cannabinoid receptor 1
([CB.sub.1]) is expressed in the central nervous system predominantly by neurons [9, 10] and modulates physiological processes, such as motor behaviour, learning, memory and cognition, and pain perception .
Human cannabinoid receptor 1
: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.
Dynamic imaging of cannabinoid receptor 1
vesicular trafficking in cultured astrocytes.
In addition, the firm will spend the money to identify and develop novel therapeutic mAbs targeting GPCRs, including a mAb to cannabinoid receptor 1
(CB-1), which is a commercially validated but previously intractable drug target.
Hornby, "Agonists of cannabinoid receptor 1
and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium," American Journal of Physiology: Gastrointestinal and Liver Physiology, vol.
Altucci et al., "Cannabinoid receptor 1
influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement," Endocrinology, vol.
Also, the psychotropic action of the phytocannabinoid THC was explained by cannabinoid receptor 1
(CB1) binding that was first cloned in 1990 (Hosking and Zajicek 2008).