CNR1

(redirected from cannabinoid receptor 1)

CNR1

A gene on chromosome 6q14-q15 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR1 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR1 is also a less preferred gene symbol for what is now designated as PCDHA4, see there.
References in periodicals archive ?
The analgesic effects of cannabinoids and their ligands are primarily mediated by the cannabinoid receptor 1 (CB1) via inhibition of presynaptic gamma-aminobutyric acid (GABA) and glutamatergic transmission.
Cannabinoid receptor 1 is the principal receptor of the central nervous system (CNS) and is densely expressed in several areas of the brain and supraspinal regions involved with nociceptive transmission.
Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin.
In addition, the firm will spend the money to identify and develop novel therapeutic mAbs targeting GPCRs, including a mAb to cannabinoid receptor 1 (CB-1), which is a commercially validated but previously intractable drug target.
Bradley Winters, lead author of the research paper and a freshly minted WSU doctor of neuroscience, said he, his major advisor Yan Dong, and colleagues at WSU, the University of Pittsburgh and the European Neuroscience Institute focused on cells that produce a signaling molecule called cannabinoid receptor 1, or CB1.
Also, the psychotropic action of the phytocannabinoid THC was explained by cannabinoid receptor 1 (CB1) binding that was first cloned in 1990 (Hosking and Zajicek 2008).