CNR1

(redirected from cannabinoid receptor 1)

CNR1

A gene on chromosome 6q14-q15 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR1 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR1 is also a less preferred gene symbol for what is now designated as PCDHA4, see there.
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References in periodicals archive ?
(39) Likewise, in another study, there was a pronounced association between a polymorphism in the cannabinoid receptor 1 (CNR1) gene and IBS symptoms, colonic transit in IBS-D, and intestinal gas.
The analgesic effects of cannabinoids and their ligands are primarily mediated by the cannabinoid receptor 1 (CB1) via inhibition of presynaptic gamma-aminobutyric acid (GABA) and glutamatergic transmission.
In 1988, Howlett's group (Devane et al., 1988) suggested the existence of a specific receptor for cannabinoids known as "cannabinoid receptor 1" or CB1, which is mainly distributed throughout the central nervous system (Burns et al., 2007; Egertova, Giang, Cravatt & Elphick, 1998; van Laere et al., 2008).
Cannabinoid receptor 1 ([CB.sub.1]) is expressed in the central nervous system predominantly by neurons [9, 10] and modulates physiological processes, such as motor behaviour, learning, memory and cognition, and pain perception [11].
Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.
In addition, the firm will spend the money to identify and develop novel therapeutic mAbs targeting GPCRs, including a mAb to cannabinoid receptor 1 (CB-1), which is a commercially validated but previously intractable drug target.
Hornby, "Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium," American Journal of Physiology: Gastrointestinal and Liver Physiology, vol.
Altucci et al., "Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement," Endocrinology, vol.
Also, the psychotropic action of the phytocannabinoid THC was explained by cannabinoid receptor 1 (CB1) binding that was first cloned in 1990 (Hosking and Zajicek 2008).