candidiasis familial type 7(redirected from candidiasis, familial, chronic mucocutaneous, autosomal dominant)
candidiasis familial type 7An autosomal dominant disorder (OMIM:614162) characterised by altered immune responses and impaired clearance of Candida.
Persistent and/or recurrent infections of skin, nails and mucous membranes caused by Candida species, primarily C albicans.
Reduced production of IFN-alpha, IL-17, and IL-22.
Caused by defects of STAT1, which encodes a STAT family transcription factor that is activated by IFN-alpha, IFN-gamma, EGF, PDGF and IL6.