ING4(redirected from candidate tumour suppressor p33 ING1 homolog)
ING4A gene on chromosome 12p13.31 that encodes inhibitor of growth (ING) family member 4, a component of the HBO1 complex responsible for the bulk of histone H4 acetylation in vivo. ING4 may inhibit tumour progression by downregulating signalling pathways which drive cell proliferation. It suppresses brain tumour angiogenesis through transcriptional repression of RELA/NFKB3 target genes.
Reduced expression of ING is linked to higher grades of gliomas and carcinomas of the breast, head and neck, and stomach.