candidate gene


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A DNA sequence in a chromosome region suspected of being involved in a particular disease of interest, whose protein product suggests that it could be the disease gene in question

candidate gene

(kăn′dĭ-dāt″)
A gene that is suspected of being responsible for a particular trait or illness.

candidate gene

a gene believed to be related to a particular disease or condition. Candidate genes can be identified on the basis of position or function. A positional candidate gene is located in a chromosomal region suspected of being linked to a disease. A functional candidate gene is a gene encoding a product connected with the disease.
References in periodicals archive ?
Further genetic analyses (i.e., candidate gene studies) have helped identify specific genes that may contribute to the development of alcohol dependence and habitual smoking.
Geneticist Bruce Lahn of the University of Chicago calls HAR1F "a strong candidate gene" for examining how changes in DNA sequence have contributed to the emergence of the distinctly human brain.
Some of the genes underlying this clinical variability have been uncovered after careful phenotypic (i.e., clinical) analysis, correlations with other distinct genetic disorders, and candidate gene analysis.
Progress in the area of plant genomics has been dramatic and the stage is set for efficient application of marker-assisted genetics, candidate gene analysis, and molecular breeding.
Follistatin was a candidate gene because of its role in regulating follicular growth and the secretion of follicle-stimulating hormone.
With similar arguments on MIS, for each candidate gene g, the maximum function score (MFS) was calculated as follows:
SNP and candidate gene annotation were retrieved using Ensembl annotation of Sscrofa 10.2 genome version in NCBI data base [10] while functional classification of candidate genes with the target chromosomal segment was investigated using DAVID online annotation tools [11].
DENND1A gene in this locus was considered as a candidate gene based on its role in regulating the production of endoplasmic reticulum amino-peptidase-1, used for membrane trafficking.18 Most recent GWAS and meta-analysis of candidate genes showed significant association of two variants in the FBN3 gene with PCOS phenotype.19 FBN3 gene encodes fibrillin-3 protein.
Blood samples of the pro-band were collected and used for screening the hereditary cerebrovascular disease related genes, such as HTRA1, APP, CST3, and ITM2B, etc., and SNP genotyping assay were then conducted on family members after identifying the candidate gene.
Melting curve, gel analysis, and sequences of each candidate gene were analyzed to verify that a single PCR product was amplified for each set of primers.
The study will augment the information available and can be applied in future studies to determine the role of buffalo FASN gene as a candidate gene marker for a milk-fat content.

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