cancer susceptibility

cancer susceptibility

An inherent proneness toward suffering from cancer.

Fringe oncology
Advocates of unproven methods of cancer care may evoke psychoneuroimmunology arguments that certain personality types or individuals with specific mental health profiles are at an increased risk of acquiring cancer.

Cancer Susceptibility—fringe oncology arguments
• Maternal domination;
• Immature sexual adjustment;
• Inability to express emotions and hostility; 
• Inability to accept significant losses;
• Pre-neoplastic feelings of despair, hopelessness and self-pity;
• Poor self-image and interpersonal relationships;
• Lack of closeness to parents.

Mainstream oncology
A tangible risk of suffering cancer, based on chromosome and DNA analysis.
References in periodicals archive ?
Presently, many genetic testing panels for cancer susceptibility are available in the market.
The laboratory seeks a broad understanding of factors related to cancer susceptibility using knowledge derived from epidemiologic studies as well as fundamental cellular and molecular biology.
The EC has approved the product as monotherapy treatment for adult patients with germline breast cancer susceptibility gene (gBRCA)1/2-mutations, who have human epidermal growth factor receptor 2-negative (HER2-) locally advanced or metastatic breast cancer.
announced that the European Commission approved TALZENNA (talazoparib), an oral poly (ADP-ribose) polymerase (PARP) inhibitor, as monotherapy for the treatment of adult patients with germline breast cancer susceptibility gene (gBRCA)1/2-mutations, who have human epidermal growth factor receptor 2-negative (HER2-) locally advanced (LA) or metastatic breast cancer (MBC).
This milestone payment was triggered by the European Commission (EC) approval of TALZENNA[R] (talazoparib) as monotherapy for the treatment of adult patients with germline breast cancer susceptibility gene (gBRCA) 1/2-mutations, who have human epidermal growth factor receptor 2-negative (HER2-) locally advanced (LA) or metastatic breast cancer (MBC).
BioMarin Pharmaceutical (BMRN) announced that the company earned a $15M milestone payment from Pfizer (PFE), triggered by the European Commission approval of Talzenna as monotherapy for the treatment of adult patients with germline breast cancer susceptibility gene 1/2-mutations, who have human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer.
Certain inherited PTEN mutations can cause syndromes characterized by cancer susceptibility and developmental defects.
Number of studies highlighted the role of XPD polymorphisms in cancer susceptibility including, lung, [5] prostate, [12] breast, [8] and head and neck cancer [3,4] among different ethnic populations, whereas other studies failed to find positive association of XPD polymorphism in the head and neck cancer [22] or breast carcinoma.
This is the first novel mutation ever reported in a Moroccan family associated with colon cancer susceptibility. Identification of such mutations is crucial and can widely aid in the management of colorectal cancer in predisposed populations through molecular screening, prevention strategies, and follow-up of suspected LS families.
On further questioning, the patient reports she had triple-negative (estrogen receptor-, progesterone receptor-, and human epidermal growth factor receptor 2 [HER2]-negative) breast cancer, a feature of patients with germline BRCA1 (breast cancer susceptibility gene 1) mutations.
'This research also provides a foundation for others to investigate the DNA loci and associated genes that play roles in skin cancer susceptibility and the effects of UV radiation."
Multiple large studies of the matched normal germ line variants in cancer patients have revealed that mutations in cancer susceptibility genes are significantly more common than previously thought (3)?

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