tumour marker

(redirected from cancer marker)

tumour marker

Any specific substance present in increased amounts in serum that may be used for early cancer (CA) detection. Most tumour markers are nonspecific and of little use as screening tools; they may be used to detect recurrence (e.g., CEA in patients with known colorectal and other CAs).  

Examples
Oncofoetal proteins (alpha-fetoprotein) for hepatic carcinoma; CA125 for ovarian CA; CEA for ovarian, lung, breast, pancreas, GI tract CAs; PSA for prostate CA.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

tu·mor mark·er

(tū'mŏr mahr'kĕr)
A substance released into the circulation by tumor tissue; its detection in the serum indicates the presence and specific type of tumor.
Synonym(s): tumour marker.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

tu·mor mark·er

(tū'mŏr mahr'kĕr)
A substance released into the circulation by tumor tissue; its detection in the serum indicates the presence and specific type of tumor.
Synonym(s): tumour marker, tumour marker.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Yen et al reported MMP-1 and MMP-10 as potential oral cancer marker by using AUCs of relative gene expression as 0.715, 0.727 and 0.513 for MMP-1, MMP-10 and MMP-12, respectively.21 While in our findings, MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80.0% and 78.9%, respectively in serum.
"Machine learning helps us get this information to patients sooner and may transform cancer care in the developing world where precise breast cancer marker assessment is in short supply."
'We can conclude that ferric citrate and ferric EDTA might be carcinogenic, as they both increase the formation of amphiregulin, a known cancer marker most often associated with long-term cancer with poor prognosis,' said lead author Nathalie Scheers.
Some trials tried to improve the diagnostic value of CA 19-9 by measuring the CA 19-9 antigen on individual proteins or combining CA 19-9 with another cancer marker.
Pembrolizumab (anti-PDI) is the first cancer drug based on a predictive cancer marker, rather than tumour type, to be approved by the US FDA.
"The blood test measures levels of an ovarian cancer marker called CA-125--but about 20 percent of women with ovarian cancer don't have elevated CA-125 levels, while about three percent of women who do have high levels don't have ovarian cancer, since CA-125 also can be raised by other conditions."
In the case of a colon cancer marker, evaluating whether chemotherapy is the right decision depends on the relative benefits and harms of chemotherapy.
After the first four months of chemotherapy, my cancer marker was in the normal range.
OPN is also implicated in tumorigenesis and has been proposed as a cancer marker [7-11].
It has been shown that small interfering RNA against KLF6-SV1 stops tumour progression in the ovary.[2] With the discovery of this new breast cancer marker, it will be possible to develop new and more effective therapeutic drugs based on KLF6-SV1 that can potentially reduce mortalities due to breast cancer.
Myriad Genetics jumped 10 percent immediately after a US Supreme Court decision that rejected its patent claims on natural DNA but allowed protection for its synthesized DNA-cDNA-and left in place its lucrative diagnostic business for the potential cancer marker BRCA1.