They used miR-429, one of a family of microRNAs previously implicated in epithelial to mesencymal changes in other cancers, to see if it could turn the mesenchymal cancer cells
back into epithelial cancer cells
But the minute size of cancer cells
can make tests deceiving.
Both isomers stimulated MCF-7 human breast cancer cell
proliferation to equivalent degrees at concentrations ranging from 0.
By activating E2F-1-mediated checkpoint pathways, these compounds are intended to kill cancer cells
selectively by activating the cell's natural defense mechanism against DNA damage.
However, prostate cancer cells
often lose the need for androgen as a survival, growth, or differentiation factor and become androgen independent (Westin and Bergh 1998).
Cyclacel's Biomarker Team used a novel assay technique to calculate the extent by which cancer cells
are committing suicide (or apoptotic index) in different patients on the drug.
A simple method to determine whole cell uptake of radiolabelled estrogen and progesterone and their subcellular localization in breast cancer cell
lines in monolayer culture.
But, cancer molecular biologists said, MAP kinase is a well-known enzyme that is associated with cell growth in general, so it is hardly surprising that it is found in high levels in cancer cells
, which are growing rapidly.
Depending on how mutations interact within a given cancer cell
, the cell may or may not survive and propagate.
The researchers tested these targeted contrast agents by injecting them into the tail veins of mice that had human breast cancer cells
implanted in their thighs.
Anti-Cell Adhesive Effects of GRN163L in Cancer Cells
Furthermore, they report in the July Cancer Cell
, there's a correlation between Jagged1's abundance and the amount of angiogenesis in the human tumors that the researchers examined.