cancer cell


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cancer cell

A malignant cell, which has several key features:
(1) Divide uncontrollably;
(2) Refuse to die—i.e., bypass programmed cell death (apoptosis); and
(3) Spread distally (matastasis) from original site via lymphatics or blood vessels.

cancer cell

A cell present in a neoplasm and differentiated from normal tissue cells because of its degree of anaplasia, irregularity of shape, nuclear size, changes in the structure of the nucleus and cytoplasm, increased number of mitoses, and ability to metastasize.
See also: cell
References in periodicals archive ?
They used miR-429, one of a family of microRNAs previously implicated in epithelial to mesencymal changes in other cancers, to see if it could turn the mesenchymal cancer cells back into epithelial cancer cells.
But the minute size of cancer cells can make tests deceiving.
Both isomers stimulated MCF-7 human breast cancer cell proliferation to equivalent degrees at concentrations ranging from 0.
By activating E2F-1-mediated checkpoint pathways, these compounds are intended to kill cancer cells selectively by activating the cell's natural defense mechanism against DNA damage.
However, prostate cancer cells often lose the need for androgen as a survival, growth, or differentiation factor and become androgen independent (Westin and Bergh 1998).
Cyclacel's Biomarker Team used a novel assay technique to calculate the extent by which cancer cells are committing suicide (or apoptotic index) in different patients on the drug.
A simple method to determine whole cell uptake of radiolabelled estrogen and progesterone and their subcellular localization in breast cancer cell lines in monolayer culture.
But, cancer molecular biologists said, MAP kinase is a well-known enzyme that is associated with cell growth in general, so it is hardly surprising that it is found in high levels in cancer cells, which are growing rapidly.
Depending on how mutations interact within a given cancer cell, the cell may or may not survive and propagate.
The researchers tested these targeted contrast agents by injecting them into the tail veins of mice that had human breast cancer cells implanted in their thighs.
Furthermore, they report in the July Cancer Cell, there's a correlation between Jagged1's abundance and the amount of angiogenesis in the human tumors that the researchers examined.

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