cancer antigen


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Related to cancer antigen: Cancer antigen 19-9, Cancer antigen 15-3

cancer antigen

Abbreviation: CA
A protein or carbohydrate that is either expressed by cancerous cells but not by healthy cells or is expressed by cancerous cells in much greater concentrations than by healthy cells. Cancer antigens are used in clinical medicine to screen body fluids for tumors or to follow the response of tumors to treatment. Since they stimulate the immune response, they are also used in the manufacture of antitumor vaccines. See: table
Note: several antigens on this list also detect benign diseases and conditions.
Antigen name or designationAbbreviationThe tumor it detects
Alpha-fetoproteinAFPNonseminomatous germ cell tumor
CA 15–3Breast cancer
CA 19–9Pancreatic cancer
CA 50Gastrointestinal tract tumors
CA 125Ovarian/peritoneal cancer
Carcinoembryonic antigenCEAGastrointestinal tract tumors and tumors of solid internal organs
Human chorionic gonadotropinHCGNonseminomatous germ cell tumors; choriocarcinoma
Microglobulin-beta 2 subunitb2–MMultiple myeloma
Neuron-specific enolaseNSEBroad variety of cancers, including small cell carcinoma of lung
NY-BR-40 and othersBreast cancer
Prostate specific antigenPSAProstate cancer
Urinary tumor associated antigenUTAAMelanoma
See also: antigen
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Receiver-operating characteristic curves for (A) the bivariable and (B) multivariable logistic regression models of combining prostate cancer antigen 3 (PCA3) score and prostate-specific antigen (PSA) level.
Family 2 is directed to cancer antigens believed to be capable of stimulating anti-cancer immune responses.
This is the first milestone payment Corixa has received under the terms of a 1999 agreement with JT, which provides JT with certain rights to develop vaccine products containing Corixa's novel lung cancer antigens, including antigens formulated using Corixa's microsphere delivery system and proprietary adjuvant technologies.
Synthesis and secretion of the ovarian cancer antigen CA125 by the human cancer cell line NIH:OVCAR-3.
The correct primary diagnosis code for this situation is 795.82 (elevated cancer antigen 125), followed by V16.41 (family history of malignant neoplasm; genital organs; ovary).
PROVENGE targets the prostate cancer antigen, prostatic acid phosphatase (PAP), which is found in approximately 95% of prostate cancers.
(Santa Monica, CA; 310-820-8029), a privately-held biotechnology company, announced a research collaboration, option and license agreement under which the parties will use Abgenix's human antibody technologies to discover and develop fully human monoclonal antibody therapies against selected cancer antigen targets supplied by Agensys.
At that point, virtually every potential breast cancer antigen will be known or will be knowable," he noted.
The company's core technology, called the Lm Technology, alters a live strain of Listeria monocytogenes (Lm) bacteria to generate cancer fighting T-cells directed against a cancer antigen and neutralizing factors that protect the tumor microenvironment from immunologic attack and contribute to tumor growth.
The urine marker prostate cancer antigen 3 (PCA3) has been shown to increase the specificity of PSA, especially for patients with repeat biopsies (11-13).
Funded by the NCI, the PLCO trial enrolled more than 150,000 men and women aged 55-74 years to be studied by various screening arms, including one to test CA 125 (cancer antigen 125) and pelvic ultrasound for ovarian cancer, between 1992 and 2001.
A new blood test for the human epididymis protein 4 can flag most epithelial ovarian cancers when used preoperatively with cancer antigen 125-II testing in women with a pelvic cyst or mass, researchers reported in Tampa, Fla., at the annual meeting of the Society of Gynecologic Oncologists.