camptothecins

camp·to·the·cins

(kamp'tō-thek'inz),
1. Antitumor agents acting as topoisomerase inhibitors; include irinotecan and topotecan.
2. A semisynthetic drug derived from camptothecin.

camptothecins

A new class of cytotoxic anticancer drugs based on the plant alkaloid camptothecin found in the wood, bark and fruit of the tree Camptotheca acuminata . Camptopthecins attack the enzyme TOPOISOMERASE. The class includes the drugs TOPOTECAN and IRINOTECAN both of which are showing promising results in the treatment of small cell lung cancer and ovarian cancer.
References in periodicals archive ?
The camptothecins definitely bind to topoisomerase I and stabilize DNA-topoisomerase I cleavable complex.
Cheng used a chemical linker to attach the camptothecins to the polymer.
Prior to this discovery, most cancer drugs have targeted binding to the major groove in DNA leading to the successful introduction of several new classes of anticancer drugs, including topoisomerase inhibitors such as camptothecins and anthracyclines.
An up-to-date summary is offered including a discussion of topoisomerase I, along with an analysis of animal models for defining the anticancer potential of camptothecins, and issues of camptothecin resistance.
Karenitecin is in the drug class known as camptothecins and has been designed to avoid problems with oral bioavailability, unfavorable metabolism, toxicity and drug resistance that have been associated with other camptothecins.
Aphios Corporation today announced that it has entered into a contract with the National Cancer Institute (NCI) to develop Tdp-1 inhibitors either as a primary therapy or in combination with camptothecins for colon, breast, ovarian, leukemia and other cancers.
The camptothecins stop cells from completing mitosis, specifically in the S-phase.
Topoisomerase inhibitors that inhibit either topoisomerase I or II are used to treat a number of different tumor types: camptothecins (topoisomerase I inhibitors) for colorectal cancer; anthracyclines (topoisomerase II inhibitors) for breast, ovarian, bladder cancer and Non Hodgkin's Lymphoma; etoposide (topoisomerase II inhibitor) for lung cancer.
Lipotecan([R]) is structurally related to topotecan and other camptothecins, but has been chemically modified to improve stability and potency and to minimize toxicity.
Camptothecins are among the most important classes of anti-cancer drugs introduced in recent years; however, the commercially available products have demonstrated toxicities that may limit their clinical utility.
Camptothecins are a rapidly growing class of anti-cancer drugs that are currently used in the treatment of colorectal, lung and ovarian cancers.
Camptothecins are an important and rapidly growing class of anti-cancer drugs that are currently used in the treatment of colon, lung and ovarian cancers.