A phase II study of CPT-11, a new derivative of
camptothecin, for previously untreated non-small-cell lung cancer.
Surface-modified silica nanoparticles for tumor-targeted delivery of
camptothecin and its biological evaluation," Journal of Controlled Release, vol.
Camptothecin shows interaction with T274 (Figure 5C) while taxol based mutants, irrespective of their higher binding energy, do not display any interactions.
Camptothecin accumulation in Ophiorrhiza rugosa var.
Interestingly, both of the
Camptothecin and 10-Hydroxycamptothecin had the same mean score ,and they were the most potent agents between the other
Camptothecins.
In most of these methods, both CPT-11 and SN-38 were quantified and the related compound
camptothecin was used as the internal standard.
Camptothecin inhibits an enzyme closely linked with cell division.
Recently, researchers at the Stehlin Foundation for Cancer Research in Houston announced impressive results treating pancreatic cancer with 9-Nitro
Camptothecin (9NC), made from the Chinese Camptotheca acuminata tree.
A natural compound called
camptothecin, concentrated mostly in the bark, was discovered to have cancer-halting properties by Houston's Stehlin Foundation for Cancer Research.
CRLX101 is a dynamically tumor-targeted nanopharmaceutical designed to concentrate in tumors and release its payload,
camptothecin, over an extended period of time, prolonging drug exposure at the site of action.
The product is an analogue of
camptothecin, a topoisomerase I inhibitor and prodrug that only becomes active when entering tumour cells.
Firstly, we will establish the genomic interacting landscape of landmark drugs including etoposide,
camptothecin and cisplatin using Drug-Seq.
