After that, cells were treated with camptothecin
(60[micro]M), taxol (300[micro]M), etoposide (600[micro]M), and cisplatinum (30[micro]M) for 6 h.
; Antifungal activity; Mechanism; Antifungal; Rhizoctonia solani
UPDATE: Although it didn't prove effective against leukemia, a synthetic version of camptothecin
is used to treat ovarian, lung and colon cancers.
Unlike the results observed with Cr(VI), phosphorylation of ATM targets CHK2-Thr68 and KAP1-S821 by the topoisomerase I poison camptothecin
was not altered by Asc restoration (Figure 2F), indicating that Asc did not act as a general suppressor of ATM signaling.
CZ-48 is an analogue of camptothecin
which is stable and resistant to inactivation while circulating in human bloodstream.
Following 48 hours of culture, the cells were treated with etoposide (0.9 [micro]M), camptothecin
(2.0 [micro]M), thapsigargin (0.32 mM), or DMSO for 18 hours.
Part two covers structure-activity details of some particular drug successes, including epothilones, taxol, camptothecin
, morphine, lincosamide, platensimycin, phlorizin, aeruginosins, and their analogs.
To begin with, the compounds from higher plants include Berbamine, Butulinic acid, Camptothecin
, Cucurbitacin, Ellipticine, Flavopiridol, Homoharringtonine, Silvestrol, Berberine, Daphnoretin and Podophyllotoxin.
From the calculated [IC.sub.50] values, it has been observed that complex E with benzoylacetone ligand shows (4.06 [micro]M) better activity than other complexes against the HeLa cell line, which is even better than known anticancer drug camptothecin
as seen in Table 5.
Liu, "Synthesis and release behavior of composites of camptothecin
and layered double hydroxide," Journal of Solid State Chemistry, vol.
Compounds 1 and 2 were screened for their anticancer activity against five human cancer cell lines by MTT assay (Table 1) with the naturally occurring [beta]-asarone and camptothecin
taken as standards.