camptothecin


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camp·to·the·cin

(kamp'tō-thek'in),
Plant alkaloids consisting of a pentacyclic structure with a lactone ring; inhibitors of topoisomerase I, that is, topotecan and irinotecan (CPT-11).
[Camptotheca, genus name of botanic source]

camp·to·the·cin

(kamp'tō-thē'sin)
Plant alkaloids consisting of a pentacyclic structure with a lactone ring; inhibitors of topoisomerase I, i.e., topotecan and irinotecan (CPT-11).
[Camptotheca, genus name of botanic source]

camptothecin

(kămp″tō-thē′sĭn),

CPT

An inhibitor of the enzyme topoisomerase I. Medications derived from this agent (including irinotecan and topotecan) are used to treat a variety of cancers.
References in periodicals archive ?
After that, cells were treated with camptothecin (60[micro]M), taxol (300[micro]M), etoposide (600[micro]M), and cisplatinum (30[micro]M) for 6 h.
Keywords: Camptothecin; Antifungal activity; Mechanism; Antifungal; Rhizoctonia solani
UPDATE: Although it didn't prove effective against leukemia, a synthetic version of camptothecin is used to treat ovarian, lung and colon cancers.
Unlike the results observed with Cr(VI), phosphorylation of ATM targets CHK2-Thr68 and KAP1-S821 by the topoisomerase I poison camptothecin was not altered by Asc restoration (Figure 2F), indicating that Asc did not act as a general suppressor of ATM signaling.
CZ-48 is an analogue of camptothecin which is stable and resistant to inactivation while circulating in human bloodstream.
Following 48 hours of culture, the cells were treated with etoposide (0.9 [micro]M), camptothecin (2.0 [micro]M), thapsigargin (0.32 mM), or DMSO for 18 hours.
Part two covers structure-activity details of some particular drug successes, including epothilones, taxol, camptothecin, morphine, lincosamide, platensimycin, phlorizin, aeruginosins, and their analogs.
To begin with, the compounds from higher plants include Berbamine, Butulinic acid, Camptothecin, Cucurbitacin, Ellipticine, Flavopiridol, Homoharringtonine, Silvestrol, Berberine, Daphnoretin and Podophyllotoxin.
From the calculated [IC.sub.50] values, it has been observed that complex E with benzoylacetone ligand shows (4.06 [micro]M) better activity than other complexes against the HeLa cell line, which is even better than known anticancer drug camptothecin as seen in Table 5.
Liu, "Synthesis and release behavior of composites of camptothecin and layered double hydroxide," Journal of Solid State Chemistry, vol.
Compounds 1 and 2 were screened for their anticancer activity against five human cancer cell lines by MTT assay (Table 1) with the naturally occurring [beta]-asarone and camptothecin taken as standards.