Guanine at position 59 is specific for camelpox virus, and this mismatch could explain the lack of sensitivity obtained with the 14-kD POX probe with this virus.
The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox.
But new research now suggests that camelpox itself could pose a threat.
It could be that only a small set of changes would be necessary for camelpox virus to infect people, " he added.
The new evidence shows that camelpox and smallpox are similar even in these regions, raising fears that camelpox could evolve to infect people.
1] Nonstandard abbreviations: VAR, variola major virus; MPV, monkeypox virus; CML, camelpox
virus; VAC, vaccinia virus; CPV, cowpox virus; FRET, fluorescence resonance energy transfer; HA, hemagglufinin gene; ENIVD, European Network for the Diagnosis of Imported Viral Diseases; and geq, genome equivalents.
Although the formation of typical A-type inclusions is restricted to cells infected with cowpox virus, ectromelia virus, and raccoonpox virus (2), the sequence coding the N-terminus of the protein is highly conserved in many viruses, including CPXV, VACV, variola virus, camelpox
virus, and ectromelia virus.
Two hundred seventy-four antiviral drug compounds were screened for activity and therapeutic indices against variola, monkeypox, cowpox, camelpox
, and vaccinia viruses by two cell culture assays.
Iraq has produced anthrax for use in Scud missiles and conducted research on camelpox
virus, which is closely related to smallpox (2).