Myoz3 gene encodes a protein containing 241AA and maps to a single domain named Calsarcin, which extends from AA1 to AA239 (see S1 Fig in Supplementary Material available online at https://doi.org/10.n55/2017/5930918).
Olson, "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins," Journal of Biological Chemistry, vol.
(2002) Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.
(2000) Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.
Therefore, it is possible that CS-3 may play a more important role in maintenance in adult than the other two members of the calsarcin family.
Calsarcins comprise a family of muscle-specific calcineurin binding proteins which play an important role in modulating the function of calcineurin in muscle cells.
Calcineurin binds to the calsarcins, a family of muscle specific proteins of the sarcomeric Z-disc, which is a focal point in the regulation of contraction both in skeletal and cardiac muscle.