calretinin


Also found in: Wikipedia.

CALB2

A gene on chromosome 16q22.2 that encodes a calcium-binding protein of the troponin C superfamily, popularly termed calretinin, which contains 6 active calcium-binding domains and plays a role in various cell functions—e.g., message targeting, intracellular calcium buffering, modulating neuronal excitability.
 
Molecular pathology
CALB2 is used as a marker of Hirschsprung disease and some cancers.

calretinin

(kal-ret′ĭn-ĭn)
A calcium-binding protein used in immunohistochemical studies to identify the presence of neuronal cells or several specific tumors, e.g., malignant mesotheliomas.
References in periodicals archive ?
(1) Similarly, sex cord antigens, such as inhibit (11-14,17,21) Wilms tumor 1 (WT1) (16) and calretinin (11,12,17,18) are negative or show only weak focal positivity in rare HCOs.
Immunohistochemically, the tumors were positive for a-inhibin (5/6) [Figure 1]d, calretinin (5/6), CD99 (6/6), and forkhead box L2 (FOXL2, 6/6) [Figure 1]e and negative for epithelial membrane antigen (0/6).
In the paraffin-embedded (permanent) sections of the mass, the slit-like spaces were thought to be the glandular parts of an adenomatoid tumor or vascular structures and they stained negative for calretinin and CK7 and positive for CD34.
IHC stains gave equivocal results for Cytokeratin AEI/AE3 and negative results for CD34, CD31, Desmin and Calretinin. These findings proved to be essentially diagnostic of synovial sarcoma.
The most commonly found marker was Cytokaratin which was present in 71.4% of the mesothelioma patients, followed by Calretinin (57.1%), and WT1 (50%).
CD99, chromogranin A, CD45, inhibin, calretinin, CA-125, ER, PR, CK7, CK20, Moc31, Tag72, myogenin, S100, and destine were negative.
Tumor cells in the lung are mostly spindle cell tumors and are negative for actin M851, desmin, calretinin and S-100 protein and focal positive for epithelial membrane antigen and AE1/AE3.
Therefore, new studies introduce calretinin as a helpful diagnostic marker for neurogenic tumor distinguishing from each other [7].
Negative staining for calretinin. Ki-67 2.2% N57 M 35 8.0 Positive staining for 4 chromogranin A and synaptophysin.
On immunostaining, tumor cells were positive for CD31, CD34, WT1, vimentin, keratins AE1/AE3, and focal CK7 and negative for CK20, PSA, PSAP, AFP, TTF1, CDX2, BerEp4, calretinin, podoplanin D2, CD45, and S100 (Figures 2(a)-2(d)).