calreticulin


Also found in: Acronyms, Wikipedia.

cal·re·tic·u·lin

(kal-re-tik'yū-lin),
Intracellular calcium-binding protein, with cell adhesion and vascular regulatory actions; found in the endoplasmic reticulum.
[calcium + (endoplasmic and cytoplasmic) reticula + -in]

calreticulin

/cal·re·tic·u·lin/ (kal″rĕ-tik´u-lin) a calcium-binding protein in the sarcoplasmic reticulum and in the endoplasmic reticulum of nonmuscle cells; its roles include calcium homeostasis, control of viral RNA replication, lymphocyte activation, and cytotoxicity.
Mentioned in ?
References in periodicals archive ?
Calreticulin mediated glucocorticoid receptor export is involved in beta-catenin translocation and Wnt signalling inhibition in human osteoblastic cells.
Finally, the recently found mutations of calreticulin (CALR) always result in +1 frame shift, which results in the expression of the common novel C-terminus.
Molecular and structural insight into the role of key residues of thrombospondin-1 and calreticulin in thrombospondin-1-calreticulin binding.
24 July 2014 - US non-profit organisation BloodCenter of Wisconsin's Diagnostic Laboratories said Wednesday it had launched a calreticulin (CALR) mutation test for detecting gene mutations in patients with myeloproliferative neoplasms (MPN), a group of rare and chronic diseases that affect blood cell formation.
Cell type specific regulation of calreticulin and Bcl-2 expression by mood stabilizer drugs.
Further studies confirmed the identity of TAase as Calreticulin Transacetylase (CRTAase) (3).
Characterization of DNA vaccines encoding the domains of calreticulin for their ability to elicit tumor-specific immunity and antiangiogenesis.
31) reported the high sensitivity of calreticulin (CRT) in detecting bladder cancer cells, but CRT has low specificity.
Autoantigens defined by experimental serum and B-cell analysis in RA syndromes in animals and humans (10) Type/nature Specificity Autoantigen Citrulline-containing peptide Keratin Perinuclear factor Savoy antigen Filaggrin Human leukocyte antigen Calpastatin Immunoglobulin (rheumatoid factor) Calreticulin Antineutrophil cytoplasmic antigen Antinuclear antibody Immunoglobulin heavy-chain protein / p68 Heteronuclear ribonucleoprotein A2 (RA33) Glucose-6-phosphate isomerase Cartilage (organ Collagen type II specific) Chondrocyte antigen 65 Large aggregating chondroitin sulfate proteoglycan (aggrecan) Human chondrocyte glycoprotein 39 Cartilage oligomeric matrix protein Non-autoantigens Bacterial heat shock protein
Protocadherin beta 11 and calreticulin expression showed significant decrease (2.
Comparative proteomic analysis of a sea urchin (Heliocidaris erythrogratntna) antibacterial response revealed the involvement of apextrin and calreticulin.