calpains


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Related to calpains: Cathepsins

cal·pains

(kal'pānz),
Calcium-dependent thiol proteinases that are cytoplasmic mammalian enzymes. Calpains of different types react in varying degrees to concentrations of calcium ions.
[calcium + suffix -pain, protease, fr. papain]

calpains

A family of proteolytic enzymes with cysteine in the catalytic site (cysteine proteases). Calpains modulate cell function, some in specific tissues, some ubiquitously. They have been implicated in a range of diseases including cancer, multiple sclerosis, diabetes, Alzheimer's disease and cataracts.
References in periodicals archive ?
The optimum proteolytic activity of calpains was observed in the fresh meat of red deer - 0.085 um/h for one gram of protein (Fig.
Goll, "Changes in the calpains and calpastatin during postmortem storage of bovine muscle," Journal of Animal Science, vol.
Spencer, "Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance," Neuromuscular Disorders, vol.
Conclusively, an uncontrolled activation of calpain has been found to be implicated in the pathophysiology of several cardiovascular disorders [57] including myocardial IRI [58], and the inhibition of calpains has been shown to attenuate myocardial stunning and reduce infarct size after ischemia reperfusion [59] (Figure 1).
Zhu, "The molecular mechanisms of calpains action on skeletal muscle atrophy," Physiological Research, vol.
Kawashima, "Identification and Characterization of Membrane-Bound Calpains in Clathrin-Coated Vesicles from Bovine Brain," European Journal of Biochemistry, vol.
Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration.
The non-significant improvement in texture in the BF muscle may be related to the low calpain values (Koohmaraie, Seideman, Schollmeyer, Dutson & Babiker, 1988), as well as the high collagen level (Hildrum et al., 2009).
Proteinase (cathepsin B, D, L and calpains) levels and conditioning rates in normal, electrically stimulated and high-ultimate pH chicken muscle.
Role of calpains in postmortem proteolysis in chicken muscle.