calpain


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Related to calpain: cathepsin, calpastatin

calpain

(kăl′pān′)
n.
A proteolytic enzyme regulated by the concentration of calcium ions.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
The research into the activity of tissue enzymes were also assessed - with regards to cathepsins and calpains - in the muscular fiber of red deer meat.
Accumulation of Ca2+ will activate calpain 3 kinase that in turn cause degradation of myofibrils.
CaSR and calpain contribute to the ischemia reperfusion injury of spinal cord.
Degradation of [alpha]-spectrin by calpain is one of the first events required for receptor internalization.
Synaptojanin-I is predominantly distributed in nerve terminals and is extremely sensitive to calpain digestion [57]; therefore, it has been taken as a novel target for degradomic calpain [51].
review the current literature on the ischemia reperfusion injury following myocardial infarction, highlighting the relevance of a calpain system, oxidative and NO-linked pathways, and ventricular remodelling discussing the evidences from a medico-legal standpoint to better understand sudden deaths following myocardial infarction [11,12].
we also analyzed EDL muscles using a combination of immunofluorescence for CM and EM and assessed proteolytic degradation by measuring calpain activity and carbonyl protein content (Figure 2).
Caspase 12 can be activated by calpain. Calpain cleaves caspase 12 and promotes its activation during ER stressinduced apoptosis [21, 22].
Also they have been evaluated as cardiovascular agents calpain inhibitors [15] and calcium antagonists [16].