The promise of calorie restriction
(CR) is so intriguing that the National Institutes of Health is launching $20 million worth of research over seven years to study CR's effect on metabolism in humans.
Physical signs of calorie restriction
include missed periods, which is linked to low bone mineral density and the risk for stress fractures.
The study, titled "2 years of calorie restriction
and cardiometabolic risk (CALERIE)," was done by a group of researchers from the Duke University Medical Center.
Compared to the control group, the calorie restriction
group experienced significant improvements in multiple cardiometabolic risk factors, including waist circumference, blood pressure, HDL cholesterol, LDL cholesterol, triglycerides, insulin sensitivity and fasting glucose, and C-reactive protein (a marker of systemic inflammation associated with multiple chronic conditions and diseases of age).
During the course of two years, participants in the study who were on a calorie restriction
diet lowered their blood pressure and levels of bad (LDL) cholesterol, and saw a 24% drop in concentrations of triglycerides, a type of fat in the blood.
This approach, the researchers suggest, could have a more positive effect on metabolic health than simple calorie restriction
. "Time-restricted eating may be more successful than calorie restriction
in controlling the negative effects of obesity, due to the hunger and irritability that makes it more difficult to stick with long-term calorie restriction
," notes Das.
The wisdom behind Intermittent Fasting !-- -- Intermittent Fasting can help you lose weight and belly fat, without calorie restriction
. IF may reduce bad' LDL cholesterol, blood triglycerides, inflammatory markers, blood sugar and insulin resistance all risk factors for heart disease.
No exercise regime works without calorie restriction
. Successful weight loss involves making small changes that you can stick to for a long time.
Unlike intermittent fasting, time-restricted eating doesn't involve deliberate calorie restriction
. "However, what we see in studies is unintentional calorie restriction
," Kirkpatrick notes.
(7) A study also showed that intermittent fasting caused less muscle loss than continuous calorie restriction
The effects mirrored those of calorie restriction
, which had previously been shown to boost longevity but is not practical for humans.
Regardless of macronutrient profile, calorie restriction
is fundamental for weight loss, glycemic control, and prevention of diabetic complications.