PDE1A

(redirected from calmodulin-dependent phosphodiesterase)

PDE1A

A gene on chromosome 2q32.1 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing cAMP and/or cGMP to AMP and GMP. As with other PDE1s, PDE1A is activated by calmodulin in the presence of Ca2+.
References in periodicals archive ?
To date, studies from animal experiments have shown that the ginseng reduced blood pressure (Kang et al., 1995), had a relaxing effect on vascular smooth muscle and anti-inflammatory properties as well as anti-stress effect (Peng et al., 1995) and inhibited calmodulin-dependent phosphodiesterase (Sharma and Kalra, 1993).
Ginsenosides are potent and selective inhibitors of some calmodulin-dependent phosphodiesterase isozymes.