In addition, manipulation of 5-HT during early development produces a reduction of tryptophan hydroxylase expression in midline subgroups of the raphe nuclear complex and a reduction in the density of Serotonin immunoreactive fibers in cortex (Weaver et al., 2010), and disturbs characteristic chemoarchitectural and electrophysiological brain features, including changes in raphe and callosal
connections, sensory processing, and myelin sheath formation (Simpson et al., 2011).
Brain MRI showed non-enhancing hyperintense signal lesions in the right cerebellar peduncle, the right lateral midbrain, the left corpus callosal
splenium, and the left temporal periventricular white matter in the T2/FLAIR image (Figure 1).
Cingulotomy for psychiatric disease: microelectrode guidance, a callosal
reference system for documenting lesion location, and clinical results.
dysgenesis/agenesis and intracranial cysts are two common intracranial malformative lesions and their association has been well documented.
A computed tomography (CT) scan of the head showed severe microcephaly with intracranial volume loss, including thinning of the cortical mantle, and callosal
and pontocerebellar hypoplasia with ex vacuo ventriculomegaly.
thinning also could be due to white matter volume loss.
There was also an associated, substantial decrease in the corpus callosum posterior midbody (P < 0.008) where the callosal
fibers are connected to the postcentral gyrus, which suggested altered white matter properties in the somatosensory pathway.
IHS is interpreted as a sign of connectivity or functional interaction between hemispheres and is hence considered an important feature of normal brain function, resulting from the development of callosal
Splenial lesions may extend into the callosal
radiations, frontoparietal subcortical white matter and to the rest of the corpus callosum.
A longitudinal study of callosal
atrophy and interhemispheric dysfunction in relapse-remitting multiple sclerosis.