Pseudomyogenic hemangioendothelioma lacks the intersecting fascicular pattern of a true smooth muscle tumor and is negative for smooth muscle markers, such as desmin, caldesmon
, and SMA.
The tumor did not stain with P16, CEA, beta HCG and P63, desmin, MyoD1, CD10, caldesmon
, and cyclinD1.
Immunohistochemically, SMA (Figure 5) and vimentin (Figure 6) were diffusely positive, and caldesmon
was focally positive in tumor cells.
On immunohistochemical examination, positive staining with vimentin, smooth-muscle actin (SMA), and caldesmon
and negative staining with pancytokeratin, S-100, and CD31 were observed in the tumor (Figure 2-5).
When the concentration of cytoplasmic [Ca.sup.2+] increases, caldesmon
(CAM) replaces Cav-1 and binds to eNOS to activate it .
Leiomyomas of deep somatic soft tissue are positive for smooth muscle actin (SMA), desmin, and caldesmon
(Figure 2) and expectedly are negative for a range of markers including cytokeratins, S100 protein, SOX-10, and CD34.
Immunohistochemically, the tumor showed strong and diffuse reactivity for smooth muscle actin and focal and moderate reactivity for desmin and caldesmon
. The proliferation index detected by Ki-67 was found to be 20%.
Its immunohistochemical features include positivity for smooth muscle actin, desmin, caldesmon
, calponin, vimentin [1, 2], and hormonal receptors (estrogen and progesterone receptors) [1, 5].
Immunohistochemically, the tumor cells were positive for vimentin, sex determining region of Y chromosome-related high-mobility group box gene-9 (SOX-9), S-100, P16, murine double minute 2 (MDM2), and cyclin-dependent kinase 4 (CDK4) and negative for pan-cytokeratin (PCK), epithelial membrane antigen (EMA), smooth muscle actin (SMA), desmin, myogenin, cluster of differentiation 10 (CD10), CD31, CD34, caldesmon
, CD99, beta-catenin, signal transducer, and activator of transcription 6 (STAT-6).
The present study is done in order to establish the prevalence of VI in stage 1 and 2 colon cancer using a caldesmon
staining technique to increase sensitivity for intra- or extramural invasion.
Read et al., "Phasic Phosphorylation of Caldesmon
and ERK 1/2 during contractions in Human Myometrium," PLoS ONE, vol.
Morgan, "ERK1/2-mediated phosphorylation of myometrial caldesmon
during pregnancy and labor," American Journal of Physiology--Regulatory, Integrative and Comparative Physiology, vol.