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An F-actin cross-linking protein that, at low or absent calcium levels, binds to tropomyosin and actin and prevents myosin binding.
[calcium + G. desmos, bond, fr. deō, to bind]
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Pseudomyogenic hemangioendothelioma lacks the intersecting fascicular pattern of a true smooth muscle tumor and is negative for smooth muscle markers, such as desmin, caldesmon, and SMA.
The tumor did not stain with P16, CEA, beta HCG and P63, desmin, MyoD1, CD10, caldesmon, and cyclinD1.
Immunohistochemically, SMA (Figure 5) and vimentin (Figure 6) were diffusely positive, and caldesmon was focally positive in tumor cells.
On immunohistochemical examination, positive staining with vimentin, smooth-muscle actin (SMA), and caldesmon and negative staining with pancytokeratin, S-100, and CD31 were observed in the tumor (Figure 2-5).
When the concentration of cytoplasmic [Ca.sup.2+] increases, caldesmon (CAM) replaces Cav-1 and binds to eNOS to activate it [23].
Leiomyomas of deep somatic soft tissue are positive for smooth muscle actin (SMA), desmin, and caldesmon (Figure 2) and expectedly are negative for a range of markers including cytokeratins, S100 protein, SOX-10, and CD34.
Immunohistochemically, the tumor showed strong and diffuse reactivity for smooth muscle actin and focal and moderate reactivity for desmin and caldesmon. The proliferation index detected by Ki-67 was found to be 20%.
Its immunohistochemical features include positivity for smooth muscle actin, desmin, caldesmon, calponin, vimentin [1, 2], and hormonal receptors (estrogen and progesterone receptors) [1, 5].
Immunohistochemically, the tumor cells were positive for vimentin, sex determining region of Y chromosome-related high-mobility group box gene-9 (SOX-9), S-100, P16, murine double minute 2 (MDM2), and cyclin-dependent kinase 4 (CDK4) and negative for pan-cytokeratin (PCK), epithelial membrane antigen (EMA), smooth muscle actin (SMA), desmin, myogenin, cluster of differentiation 10 (CD10), CD31, CD34, caldesmon, CD99, beta-catenin, signal transducer, and activator of transcription 6 (STAT-6).
The present study is done in order to establish the prevalence of VI in stage 1 and 2 colon cancer using a caldesmon staining technique to increase sensitivity for intra- or extramural invasion.
Read et al., "Phasic Phosphorylation of Caldesmon and ERK 1/2 during contractions in Human Myometrium," PLoS ONE, vol.
Morgan, "ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor," American Journal of Physiology--Regulatory, Integrative and Comparative Physiology, vol.