Histologically it is characterized by a diffuse infiltration of the colonic mucosa by sheets of large macrophages with eosinophilic granular cytoplasm and characteristic cytoplasmic calcospherites
(Michaelis-Gutmann bodies), which are typically positive with Prussian blue and von Kossa stains.
INTRODUCTION: Pulmonary Alveolar Microlithiasis is rare diffuse lung disease of unknown Cause in which diffuse accumulation of numerous calcospherites
in the alveolar space with or without thickened interstitium.
(10) Confirmatory diagnosis can be established by open lung or transbronchial biopsy, showing intra-alveolar calcospherites
, which in turn represent laminated calcium phosphate concretions.
(17) Furthermore, biglycan was able to increase the coalescence of calcospherites
(21) and apatite formation.
(psammoma or calcific bodies) may be seen.
Many of Wagge's conclusions were formed by Iris earlier experiments (Wagge 1951) that showed migrating epithelial cells were responsible for secretion of both the organic membranes and the crystals of calcium carbonate within the calcospherites
(3,7) When stippled with spherical calcium deposits (calcospherites
), they have been likened to a mulberry or tapioca.
(1) It is characterized by circumscription or encapsulation, trabecular growth pattern, polygonal and elongated cells, nuclear cytoplasmic inclusions and grooves, hyaline material, dilated sinusoids, laminated calcospherites
, and cytoplasmic yellow bodies.
(psammoma bodies i.e., concentrically laminated calcium deposits) (figure 2, B)
Ganglioglioma often presents radiologically as a mural nodule within a cyst and exhibits several helpful diagnostic features, including higher cellularity, dysmorphic or binucleate neurons unassociated with pink cells, pilocytic morphology of the glial component, calcospherites
, desmoplasia, and perivascular lymphocytic infiltrates.
Microscopically, malakoplakia is characterized by aggregates of histiocytes, the Von Hanseman cells, with Michaelis-Gutmann calcospherites
. Surrounding inflammatory cells usually consist of lymphocytes and plasma cells.
Previous reports of fine-needle aspiration of dermoid cysts from other sites have demonstrated various cytologic findings, including nucleated and anucleated squamous cells, hair, keratinous debris, cholesterol, calcospherites
(calcium deposits), and inflammatory cells.