calcium sensitiser

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calcium sensitiser

Any of a new class of inotropic agents—e.g., levosimendan—that relax coronary smooth muscle and induce vasodilation by opening ATP-dependent K-channels in vascular smooth muscle. Calcium sensitisers may be useful in managing congestive heart failure.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure.
In a series of studies presented at the meeting, the cardiac improvements seen during and after 24-hour intravenous infusions of the investigational calcium sensitizer were shown to be comparable to those achieved after a 48-hour infusion, Dr.
The calcium sensitizer levosimendan attenuates endotoxin evoked myocardial dysfunction in isolated guinea pig hearts.
Levosimendan is a calcium sensitizer that works through a unique triple mechanism of action.
The patient suffered cardiac arrest (Figure 2) and was treated with catecholamines as well as a calcium sensitizer (Levosimendan, Simdax[R], Orion Corporation, Espoo, Finland), but for stabilization an Impella CP (Abiomed Inc., Danvers, MA, USA) was necessary (Figure 3).
Tenax Therapeutics is reportedly focused on its Phase 3 development programme for levosimendan, a calcium sensitizer for the reduction of morbidity and mortality in cardiac surgery patients at risk for developing Low Cardiac Output Syndrome (LCOS).
Abstract: Pimobendan is a phosphodiesterase (PDE) inhibitor and calcium sensitizer with inotropic, lusitropic, and rasodilator properties used in the treatment of congestive heart failure.
(9.) Perrone SV, Kaplinsky EJ: Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure.
"We found that the calcium sensitizer levosimendan improves the mechanical efficiency of the human diaphragm, suggesting a new, therapeutic approach to improve respiratory muscle function in patients with respiratory failure," said Leo Heunks, M.D.
Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function.
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