Pharmacodynamics and safety of a new calcium sensitizer
, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure.
In a series of studies presented at the meeting, the cardiac improvements seen during and after 24-hour intravenous infusions of the investigational calcium sensitizer
were shown to be comparable to those achieved after a 48-hour infusion, Dr.
The calcium sensitizer
levosimendan attenuates endotoxin evoked myocardial dysfunction in isolated guinea pig hearts.
Levosimendan is a calcium sensitizer
that works through a unique triple mechanism of action.
The patient suffered cardiac arrest (Figure 2) and was treated with catecholamines as well as a calcium sensitizer
(Levosimendan, Simdax[R], Orion Corporation, Espoo, Finland), but for stabilization an Impella CP (Abiomed Inc., Danvers, MA, USA) was necessary (Figure 3).
Tenax Therapeutics is reportedly focused on its Phase 3 development programme for levosimendan, a calcium sensitizer
for the reduction of morbidity and mortality in cardiac surgery patients at risk for developing Low Cardiac Output Syndrome (LCOS).
Abstract: Pimobendan is a phosphodiesterase (PDE) inhibitor and calcium sensitizer
with inotropic, lusitropic, and rasodilator properties used in the treatment of congestive heart failure.
(9.) Perrone SV, Kaplinsky EJ: Calcium sensitizer
agents: a new class of inotropic agents in the treatment of decompensated heart failure.
The use of the novel calcium sensitizer
levosimendan in critically ill patients.
"We found that the calcium sensitizer
levosimendan improves the mechanical efficiency of the human diaphragm, suggesting a new, therapeutic approach to improve respiratory muscle function in patients with respiratory failure," said Leo Heunks, M.D.
Electrophysiologic effects of a calcium sensitizer
inotrope levosimendan administered intravenously in patients with normal cardiac function.