(1) It is shown that there is the basal calcium current
through CatSper, which is blocked by NNC55-0396 (NNC).
Figure 4(a) shows the calcium current
at V = 0 mV, for different numbers of non-inactivating CaVs, while Figure 4(b) shows the corresponding cases with inactivating CaVs.
This not only resembled in vivo tissue in terms of the parallel arrangement of cells but also showed presence of antigrade calcium current
as seen in the functional heart tissue.
The depolarization to burst phase is caused by low calcium current
which can be generated in our model by setting I with a low value.
Penner, "Depletion of intracellular calcium stores activates a calcium current
in mast cells," Nature, vol.
In addition, voltage clamp measurements were performed to show that phenylpropanoid glycosides significantly inhibited the L-type calcium current
, reduced the repolarizing current [I.sub.Kr], and prolonged the AP duration .
In ventricular myocytes, the L-type calcium current
regulates excitation contraction coupling and influences the plateau height of the action potential, as well as total action potential duration .
(1996) Presynaptic calcium current
modulation by a metabotropic glutamate receptor.
Effects of terpenoid phenol derivatives on calcium current
in canine and human ventricular cardiomyocytes.
ER agonists can also decrease L-type calcium current
(mechanism 5; Jiang et al.
Nelson et al., "Cell-specific alterations of T-type calcium current
in painful diabetic neuropathy enhance excitability of sensory neurons," Journal of Neuroscience, vol.
Li, "Epidermal growth factor reduces L-type voltage-activated calcium current
density in GH4C1, rat pituitary cells," Neuroendocrinology, vol.