calcium current

calcium current

A term for the flow of Ca2+ through specific channels, which is critical for the release of neurotransmitters from presynaptic vesicles. Voltage-gated calcium channels are divided according to the type of calcium current with which they are associated.

Calcium current types
L—Long-lasting activation.
N—Neural type.
P—Purkinje activation related to the release of neurotransmitters.
R—Poorly understood; found in cerebellar granule cells.
T—Transient activatation.
References in periodicals archive ?
(1) It is shown that there is the basal calcium current through CatSper, which is blocked by NNC55-0396 (NNC).
Figure 4(a) shows the calcium current at V = 0 mV, for different numbers of non-inactivating CaVs, while Figure 4(b) shows the corresponding cases with inactivating CaVs.
This not only resembled in vivo tissue in terms of the parallel arrangement of cells but also showed presence of antigrade calcium current as seen in the functional heart tissue.
The depolarization to burst phase is caused by low calcium current which can be generated in our model by setting I with a low value.
Penner, "Depletion of intracellular calcium stores activates a calcium current in mast cells," Nature, vol.
In addition, voltage clamp measurements were performed to show that phenylpropanoid glycosides significantly inhibited the L-type calcium current, reduced the repolarizing current [I.sub.Kr], and prolonged the AP duration [37].
In ventricular myocytes, the L-type calcium current regulates excitation contraction coupling and influences the plateau height of the action potential, as well as total action potential duration [15].
(1996) Presynaptic calcium current modulation by a metabotropic glutamate receptor.
Effects of terpenoid phenol derivatives on calcium current in canine and human ventricular cardiomyocytes.
ER agonists can also decrease L-type calcium current (mechanism 5; Jiang et al.
Nelson et al., "Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons," Journal of Neuroscience, vol.
Li, "Epidermal growth factor reduces L-type voltage-activated calcium current density in GH4C1, rat pituitary cells," Neuroendocrinology, vol.