(1) It is shown that there is the basal
calcium current through CatSper, which is blocked by NNC55-0396 (NNC).
Figure 4(a) shows the
calcium current at V = 0 mV, for different numbers of non-inactivating CaVs, while Figure 4(b) shows the corresponding cases with inactivating CaVs.
This not only resembled in vivo tissue in terms of the parallel arrangement of cells but also showed presence of antigrade
calcium current as seen in the functional heart tissue.
The depolarization to burst phase is caused by low
calcium current which can be generated in our model by setting I with a low value.
Penner, "Depletion of intracellular calcium stores activates a
calcium current in mast cells," Nature, vol.
In addition, voltage clamp measurements were performed to show that phenylpropanoid glycosides significantly inhibited the L-type
calcium current, reduced the repolarizing current [I.sub.Kr], and prolonged the AP duration [37].
In ventricular myocytes, the L-type
calcium current regulates excitation contraction coupling and influences the plateau height of the action potential, as well as total action potential duration [15].
(1996) Presynaptic
calcium current modulation by a metabotropic glutamate receptor.
Effects of terpenoid phenol derivatives on
calcium current in canine and human ventricular cardiomyocytes.
ER agonists can also decrease L-type
calcium current (mechanism 5; Jiang et al.
Nelson et al., "Cell-specific alterations of T-type
calcium current in painful diabetic neuropathy enhance excitability of sensory neurons," Journal of Neuroscience, vol.
Li, "Epidermal growth factor reduces L-type voltage-activated
calcium current density in GH4C1, rat pituitary cells," Neuroendocrinology, vol.