They are widely distributed in the CNS and PNS and both have potent vasodilator activity .They exert their actions through specific receptors which are GPCRs formed by three components: the 7-transmembrane calcitonin receptor-like receptor (CRLR), the receptor component protein (RCP), and the receptor activity-modifying protein (RAMP) 1-3 .
Hsu, "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes," Journal of Biological Chemistry, vol.
AM induces its biological effects by modifying the activity of the calcitonin receptor-like receptor/receptor activity-modifying protein 2 or 3 receptor complex [10, 11].
AM binds to a heterodimeric plasma-membrane receptor composed of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein- (RAMP-) 2 or 3 [10, 11].
The association of another G protein-coupled receptors (GPCRs), the calcitonin receptor-like receptor (CLR), and RAMP1 generates the [[alpha]-CGRP.sub.8-37] sensitive CGRP1 receptor.
Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?
In the vasculature, the relaxant response induced by AM is mediated by the seven-transmembrane G protein-coupled calcitonin receptor-like receptor (CRLR), which coassembles with Subtypes 2 and 3 of the receptor activity-modifying protein (RAMP) family, thus forming a receptor-coreceptor system (9,10).
Representative immunohistochemical photomicrographs of adrenomedullin (AM) and calcitonin receptor-like receptor (CRLR) in rat cavernosal smooth muscle sections.