net) announced today that preclinical in vivo screening of a series of synthetic analogs of calcitonin gene-related peptide
('CGRP'), which naturally occurs in humans, retained the properties of CGRP at equal or greater potency.
today announced the dosing of the first patients in a proof-of-concept Phase 2 clinical study of its antibody therapeutic candidate, ALD403, targeting calcitonin gene-related peptide (CGRP) for treatment of migraine.
The company's second therapeutic program, an investigational monoclonal antibody for migraine, ALD403, inhibits a well-validated molecule shown to trigger migraine attacks, calcitonin gene-related peptide (CGRP), and is now in clinical trials.
Though we have not yet tested LipiGesic M's effect on the calcitonin gene-related peptide
(CGRP) marker that was highlighted in the August 7, Wall Street Journal article," said Mitchell, "we do know that LipiGesic M is very effective in blocking the three other markers known to play a role in the development migraine.
Therapeutic Targets Well-Validated Biology through Inhibition of Calcitonin Gene-Related Peptide
However, the emergence of Merck's first-in-class calcitonin gene-related peptide
receptor antagonist telcagepant as an alternative to triptan therapy will help counteract market losses -- according to the report, telcagepant will garner sales of $1.
Of the novel drug classes expected to launch for pain through 2023, the calcitonin gene-related peptide
receptor antagonists, growth factor modulators, and subtype-selective ion channel modulators will have the most growth impact owing to their potential efficacy advantages over existing drug classes.
Nasdaq: UGNE) said its recombinant calcitonin gene-related peptide
(CGRP) accelerated bone growth and prevented bone loss in female rats, suggesting it may do the same in postmenopausal women.
The facility also has been designed to take advantage of the time and cost savings of Unigene's patented process for the production of other peptide hormones such as growth hormone releasing factor and calcitonin gene-related peptide
A search of the GAD literature stated that acetylcholine, [gamma]-aminobutyric acid, dopamine, calcitonin gene-related peptides
, choline acetyl-transferase, and enkephalins are involved with the metabolism of GAD.
Topics of specific papers include regulation of cardiovascular control mechanisms, inflammation, aldosterone and vascular damage, calcitonin gene-related peptides
and hypertension, the renal dopaminergic system, salt sensitivity, insulin resistance, fatty acids, cell signaling, goal-oriented hypertension management, the role of nitric oxide, the Kallikrein-Kinin system, sex steroids, and the lipoxygenase system in the vasculature.