calcitonin gene-related peptide


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cal·ci·to·nin gene-re·lat·ed pep·tide (CGRP),

a second product transcribed from the calcitonin gene. CGRP is found in nervous and other tissues. It is a vasodilator that may participate in the cutaneous triple response.

cal·ci·to·nin gene-re·lat·ed pep·tide

(CGRP) (kal-si-tō'nin jēn-rĕ-lāt'ĕd pep'tīd)
A second product transcribed from the calcitonin gene. CGRP is found in a number of tissues including nervous tissue. It is a vasodilator that may participate in the cutaneous triple response.
References in periodicals archive ?
Calcitonin gene-related peptide (CGRP): a new target for migraine.
Li, "Involvement of calcitonin gene-related peptide in the depressor effects of losartan and perindopril in rats," European Journal of Pharmacology, vol.
We have also shown that epineurial arterioles are innervated by sensory nerves expressing calcitonin gene-related peptide and that the calcitonin gene-related peptide is a very potent vasodilator of these vessels and this vasodilation is impaired by diabetes [27].
Differential calcitonin gene-related peptide (CGRP) and amylin binding sites in nucleus accumbens and lung: potential models for studying CGRP/amylin receptor subtypes.
These studies are the first to test monoclonal antibodies for the prevention of migraine, and both are directed against a relatively new target in migraine prevention, the calcitonin gene-related peptide, or CGRP.
Potential mechanisms underlying the physiological responses to DKT have been investigated in animal models and include elevated levels of plasma vasoactive intestinal polypeptide [14, 17, 20], substance P [14, 17, 21, 22], motilin [23-25], and acetylcholine [10,11,13, 26-28], which promote gastrointestinal motility, as well as calcitonin gene-related peptide (CGRP) [14,15,17,21] and adrenomedullin [15,16,29, 30], which increase intestinal blood flow.
Sundler, "Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance P," Neuroscience, vol.26, no.
Quantitation of calcitonin gene-related peptide mRNA and Neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser.
ALD403 is Alder's calcitonin gene-related peptide (CGRP) inhibiting antibody therapeutic for treatment of migraine.
Calcitonin gene-related peptide (CGRP) was discovered by Amara and Colleagues in 1982.

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