calcitonin gene-related peptide


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cal·ci·to·nin gene-re·lat·ed pep·tide (CGRP),

a second product transcribed from the calcitonin gene. CGRP is found in nervous and other tissues. It is a vasodilator that may participate in the cutaneous triple response.

cal·ci·to·nin gene-re·lat·ed pep·tide

(CGRP) (kal-si-tō'nin jēn-rĕ-lāt'ĕd pep'tīd)
A second product transcribed from the calcitonin gene. CGRP is found in a number of tissues including nervous tissue. It is a vasodilator that may participate in the cutaneous triple response.
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References in periodicals archive ?
Calcitonin gene-related peptide (CGRP): a new target for migraine.
CoQ10 Targets the Cause of Migraine Headache
Li, "Involvement of calcitonin gene-related peptide in the depressor effects of losartan and perindopril in rats," European Journal of Pharmacology, vol.
Evidence That ADAM17 Mediates the Protective Action of CGRP against Angiotensin II-Induced Inflammation in Vascular Smooth Muscle Cells
We have also shown that epineurial arterioles are innervated by sensory nerves expressing calcitonin gene-related peptide and that the calcitonin gene-related peptide is a very potent vasodilator of these vessels and this vasodilation is impaired by diabetes [27].
Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats
Diverse actions of calcitonin gene-related peptide on intracellular free Ca2+ concentrations in UMR 106 osteoblastic cells.
Osseointegration of Hydroxyapatite Implants in Rat Tibial Defects with Sciatic Nerve Injury/Oseointegracion de Implantes de Hidroxiapatita en Defectos Tibiales de Ratas con Lesion del Nervio Ciatico
Differential calcitonin gene-related peptide (CGRP) and amylin binding sites in nucleus accumbens and lung: potential models for studying CGRP/amylin receptor subtypes.
Intrathecal amylin and salmon calcitonin affect formalin induced c-Fos expression in the spinal cord of rats
AM: adrenomedullin; CGRP: calcitonin gene-related peptide.
Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle
These studies are the first to test monoclonal antibodies for the prevention of migraine, and both are directed against a relatively new target in migraine prevention, the calcitonin gene-related peptide, or CGRP.
New drugs could prevent migraine attacks from occurring
Potential mechanisms underlying the physiological responses to DKT have been investigated in animal models and include elevated levels of plasma vasoactive intestinal polypeptide [14, 17, 20], substance P [14, 17, 21, 22], motilin [23-25], and acetylcholine [10,11,13, 26-28], which promote gastrointestinal motility, as well as calcitonin gene-related peptide (CGRP) [14,15,17,21] and adrenomedullin [15,16,29, 30], which increase intestinal blood flow.
Traditional Japanese medicine Daikenchuto improves functional constipation in poststroke patients
Sundler, "Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance P," Neuroscience, vol.26, no.
Significant increase in salivary substance P level after a single oral dose of cevimeline in humans
Quantitation of calcitonin gene-related peptide mRNA and Neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser.
Effects of laser therapy (680 nm) on recovery of the sciatic nerve in rabbits
ALD403 is Alder's calcitonin gene-related peptide (CGRP) inhibiting antibody therapeutic for treatment of migraine.
Alder BioPharmaceuticals Closes $38 Million Series D Financing
Calcitonin gene-related peptide (CGRP) was discovered by Amara and Colleagues in 1982.
Why is periodontitis painless?

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